Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention

Figure 2

Changes in plasma volume in PPAR𝛾^f/f and CD PPARγ knockout mice following rosiglitazone (RGZ) treatment (adapted from [28]). (a) Hematocrit (Hct) in PPAR𝛾^f/f and CD PPARγ knockout mice before and after RGZ treatment. (b) Plasma aldosterone levels in PPAR𝛾^f/f and CD PPARγ knockout mice following RGZ treatment. (c) Determination of plasma volume in PPAR𝛾^f/f and CD PPARγ KO mice by the Evans blue (EB) dye technique.

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