PPAR and Agonists against Cancer: Rational Design of Complementation Treatments
Figure 3
PPARγ effects in cancer cells. (a) The induction of Cdk inhibitor, p27 causes growth arrest due to reduced MCM7 activity and subsequent blockade of replication. (b) The induction of GADD45 impairs Cyclin B and causes
G2M growth arrest. In addition, the activation of JNK and p38 kinases via MEKK4
initiates cell death by apoptosis. (c) PPARγ activation by hormones and nutrition in
normal cells and by agonists in cancer cells may activate the differentiation programs.
