Effects of Chronic PPAR-Agonist Treatment on Cardiac Structure and Function, Blood Pressure, and Kidney in Healthy Sprague-Dawley Rats

Figure 4

Aldosterone activity and excretion. (a) urinary sodium to potassium ratio (Na:K) and (b) aldosterone excretion in normal male SD rats chronically treated with vehicle (VEH), PD168 at the dose of 10 mg/kg⋅body weight (PD-10) or with PD168 at the dose of 50 mg/kg⋅body weight (PD-50), (𝑛=10/treatment group). Means were compared using one-way ANOVA followed by Holm-Sidak test. Data are represented as means ± SEM. Different letters represent significant differences between the groups with “A” being highest mean and so forth (𝑝<0.05 was considered significant).

(a)

(b)