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PPAR Research
Volume 2009, Article ID 345320, 13 pages
http://dx.doi.org/10.1155/2009/345320
Review Article

Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor- and Plasminogen Activator Inhibitor-1

1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7035, USA
2Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
3Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

Received 3 February 2009; Revised 18 May 2009; Accepted 10 June 2009

Academic Editor: Sarah J. Roberts-Thomson

Copyright © 2009 Jennifer C. Carter and Frank C. Church. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Breast cancer is the most prominent cancer among females in the United States. There are a number of risk factors associated with development of breast cancer, including consumption of a high-fat diet and obesity. Plasminogen activator inhibitor-1 (PAI-1) is a cytokine upregulated in obesity whose expression is correlated with a poor prognosis in breast cancer. As a key mediator of adipogenesis and regulator of adipokine production, peroxisome proliferator-activated receptor- (PPAR- ) is involved in PAI-1 expression from adipose tissue. We summarize the current knowledge linking PPAR- and PAI-1 expression to high-fat diet and obesity in the risk of breast cancer.