Role of PPAR in the Control of Torpor through FGF21-NPY Pathway: From Circadian Clock to Seasonal Change in Mammals
Role of PPARα in the control of torpor through FGF21-NPY pathway. Environmental changes like food (fasting) and light enter the body from PPARα and clock gene products, Clock/Bmal, respectively. Clock/Bmal regulated-rhythmic PPARα expression. PPARα directly transactivate FGF21 and FGF21 may enter brain and effect the expression of Neuropeptide Y(NPY). NPY can induce torper through Y1 receptor for NPY.
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