New Target Genes for the Peroxisome Proliferator-Activated Receptor-𝛾 (PPAR𝛾) Antitumour Activity: Perspectives from the Insulin Receptor

Figure 2

Proposed model for the action of PPAR𝛾 in the context of the IR gene. AP-2𝛼 overexpression accounts for increased IR expression in both breast cancer cell lines and breast cancer tissues [31]. In this model, interactions between AP-2𝛼 and Sp1 in the preinitiation complex at the IR promoter are facilitated and stabilized by HMGA1. By binding to AP-2𝛼 and Sp1, PPAR𝛾 may attenuate the stimulatory role of AP-2𝛼 in IR gene expression in breast cancer.

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