The Role of the PGC1𝛼 Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy

Figure 1

Association of the PPARGC1A Ser⁴⁸² allele with weight gain in all quartiles of males with T1DM on intensive diabetes therapy. The frequency of the Ser allele in Q1 (N  =  126) was 0.23; Q2 (N  =  172) was 0.34; Q3 (N  =  158) was 0.38; Q4 (N  =  102) was 0.45. The Ser allele was significantly associated with a trend for higher weight gain with a P-value of .004 (Chi-square with 3 degrees of freedom), and a P-value of .0004 (trend, Cochran-Armitage).