Research Article

The Role of the PGC1 Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy

Table 2

Genotype and allele frequencies of the variants in candidate genes examined for association with weight gain by DCCT subjects on intensive diabetes therapy. N, number of subjects; the P-values compare genotype and minor allele frequencies between quartile 1 (Q1) and quartile 4 (Q4) of weight gain; NS, statistically not significant. The brackets indicate that heterozygotes and homozygotes for the minor allele were combined for comparisons between quartiles.

Gene/polymorphism Frequency in females Frequency in males
Q1 (N, %) Q4 (N, %) P Q1 (N, %) Q4 (N, %) P

PPARG2
Pro/Pro 52 (82.5)62 (78.5)NS 45 (75.0)42 (84.2)NS
Pro/Ala11 (17.5) 17 (21.5)NS15 (25.0)9 (17.6)NS
Ala/Ala 0 (0)0 (0) 0 (0) 0 (0) NS
Allele frequency0.090.11NS 0.130.09NS

PPARGC1A
Gly/Gly 25 (40.3)30 (38.0) NS35 (58.3)12 (23.5) .0054
Gly/Ser NS .0131
Ser/Ser
Frequency of Ser0.37 0.35 NS0.23 0.45 .0050

PPARGC1A
28 (45.2)35 (44.9)NS25 (42.3) 28 (54.9)NS
NS NS
C/C
Frequency of C0.330.30 NS0.350.27NS

HSD11B1
C/C41 (66.1)50 (59.5)NS42 (66.7)32 (62.7)NS
C/T NS NS
T/T
Frequency of T0.190.23 NS0.210.21NS

GNB3
C/C34 (54.8) 35 (44.3)NS30 (50.0)28 (54.9)NS
C/T NS NS
T/T
Frequency of T0.270.35 NS0.310.27 NS

NRC31
G/G27 (42.2)41 (52.6)NS29 (48.3)25 (49.0)NS
G/T NS NS
T/T
Frequency of T0.350.26 NS0.330.27NS

ADIPOQ
C/C32 (52.5)49 (62.0)NS32 (53.3)30 (58.8)NS
C/G NS NS
G/G
Frequency of G0.300.23 NS0.250.25 NS

NPY
G/G19 (30.6)21 (26.6)NS 15 (25.0) 10 (19.6)NS
G/A NS NS
A/A
Frequency of A0.460.52 NS0.480.54 NS

FTO
TT23 (36.0)29 (35.0) NS16 (25.4)13 (27.1)NS
TA32 (50.0)40 (48.2) NS35 (55.6)25 (52.1) NS
AA9 (14.0) 14 (17.0) NS12 (19.0)10 (20.8) NS
Frequency of A0.39 0.41 NS0.470.47 NS