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PPAR Research
Volume 2009, Article ID 706283, 11 pages
http://dx.doi.org/10.1155/2009/706283
Research Article

The PPAR Ligand GW501516 Reduces Growth but Not Apoptosis in Mouse Inner Medullary Collecting Duct Cells

Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5

Received 26 August 2008; Revised 12 December 2008; Accepted 5 January 2009

Academic Editor: Xiong Ruan

Copyright © 2009 Jordan Clark et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. L. Hébert, R. M. Breyer, H. R. Jacobson, and M. D. Breyer, “Functional and molecular aspects of prostaglandin E receptors in the cortical collecting duct,” Canadian Journal of Physiology and Pharmacology, vol. 73, no. 2, pp. 172–179, 1995. View at Google Scholar
  2. M. D. Breyer, L. Davis, H. R. Jacobson, and R. M. Breyer, “Differential localization of prostaglandin E receptor subtypes in human kidney,” American Journal of Physiology, vol. 270, no. 5, part 2, pp. F912–F918, 1996. View at Google Scholar
  3. M. D. Breyer and R. M. Breyer, “G protein-coupled prostanoid receptors and the kidney,” Annual Review of Physiology, vol. 63, pp. 579–605, 2001. View at Publisher · View at Google Scholar
  4. H. Lim and S. K. Dey, “PPARδ functions as a prostacyclin receptor in blastocyst implantation,” Trends in Endocrinology and Metabolism, vol. 11, no. 4, pp. 137–142, 2000. View at Publisher · View at Google Scholar
  5. Y. Guan, “Targeting peroxisome proliferator-activated receptors (PPARs) in kidney and urologic disease,” Minerva Urologica e Nefrologica, vol. 54, no. 2, pp. 65–79, 2002. View at Google Scholar
  6. C.-M. Hao, R. Redha, J. Morrow, and M. D. Breyer, “Peroxisome proliferator-activated receptor δ activation promotes cell survival following hypertonic stress,” The Journal of Biological Chemistry, vol. 277, no. 24, pp. 21341–21345, 2002. View at Publisher · View at Google Scholar
  7. D. Wang, H. Wang, Q. Shi et al., “Prostaglandin E2 promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor d,” Cancer Cell, vol. 6, no. 3, pp. 285–295, 2004. View at Publisher · View at Google Scholar
  8. R. A. Gupta, J. Tan, W. F. Krause et al., “Prostacyclin-mediated activation of peroxisome proliferator-activated receptor d in colorectal cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 24, pp. 13275–13280, 2000. View at Publisher · View at Google Scholar
  9. F. S. Harman, C. J. Nicol, H. E. Marin, J. M. Ward, F. J. Gonzalez, and J. M. Peters, “Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis,” Nature Medicine, vol. 10, no. 5, pp. 481–483, 2004. View at Publisher · View at Google Scholar
  10. D. Wang, H. Wang, Y. Guo et al., “Crosstalk between peroxisome proliferator-activated receptor d and VEGF stimulates cancer progression,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 50, pp. 19069–19074, 2006. View at Publisher · View at Google Scholar
  11. Y. Guan, “Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome,” Journal of the American Society of Nephrology, vol. 15, no. 11, pp. 2801–2815, 2004. View at Publisher · View at Google Scholar
  12. E. Letavernier, J. Perez, E. Joye et al., “Peroxisome proliferator-activated receptor ß/d exerts a strong protection from ischemic acute renal failure,” Journal of the American Society of Nephrology, vol. 16, no. 8, pp. 2395–2402, 2005. View at Publisher · View at Google Scholar
  13. T. Hatae, M. Wada, C. Yokoyama, M. Shimonishi, and T. Tanabe, “Prostacyclin-dependent apoptosis Mediated by PPARδ,” The Journal of Biological Chemistry, vol. 276, no. 49, pp. 46260–46267, 2001. View at Publisher · View at Google Scholar
  14. Y. H. Kim and H. J. Han, “High-glucose-induced prostaglandin E2 and peroxisome proliferator-activated receptor δ promote mouse embryonic stem cell proliferation,” Stem Cells, vol. 26, no. 3, pp. 745–755, 2008. View at Publisher · View at Google Scholar
  15. M. C. Jarvis, T. J. B. Gray, and C. N. A. Palmer, “Both PPARγ and PPARδ influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line,” Oncogene, vol. 24, no. 55, pp. 8211–8215, 2005. View at Publisher · View at Google Scholar
  16. J. Zhang, M. Fu, X. Zhu et al., “Peroxisome proliferator-activated receptor d is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells,” The Journal of Biological Chemistry, vol. 277, no. 13, pp. 11505–11512, 2002. View at Publisher · View at Google Scholar
  17. L. Khandrika, F. J. Kim, A. Campagna, S. Koul, R. B. Meacham, and H. K. Koul, “Primary culture and characterization of human renal inner medullary collecting duct epithelial cells,” The Journal of Urology, vol. 179, no. 5, pp. 2057–2063, 2008. View at Publisher · View at Google Scholar
  18. J. Taniguchi and M. Imai, “Computer analysis of the significance of the effective osmolality for urea across the inner medullary collecting duct in the operation of a single effect for the counter-current multiplication system,” Clinical and Experimental Nephrology, vol. 10, no. 4, pp. 236–243, 2006. View at Publisher · View at Google Scholar
  19. Z. Zhang, Q. Cai, L. Michea, N. I. Dmitrieva, P. Andrews, and M. B. Burg, “Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture,” American Journal of Physiology, vol. 283, no. 2, pp. F302–F308, 2002. View at Google Scholar
  20. M. B. Burg, “Renal osmoregulatory transport of compatible organic osmolytes,” Current Opinion in Nephrology and Hypertension, vol. 6, no. 5, pp. 430–433, 1997. View at Publisher · View at Google Scholar
  21. M. B. Burg, J. D. Ferraris, and N. I. Dmitrieva, “Cellular response to hyperosmotic stresses,” Physiological Reviews, vol. 87, no. 4, pp. 1441–1474, 2007. View at Publisher · View at Google Scholar
  22. T. Yang, J. B. Schnermann, and J. P. Briggs, “Regulation of cyclooxygenase-2 expression in renal medulla by tonicity in vivo and in vitro,” American Journal of Physiology, vol. 46, no. 1, pp. F1–F9, 1999. View at Google Scholar
  23. N. L. Kizer, B. Lewis, and B. A. Stanton, “Electrogenic sodium absorption and chloride secretion by an inner medullary collecting duct cell line (mIMCD-K2),” American Journal of Physiology, vol. 268, no. 2, part 2, pp. F347–F355, 1995. View at Google Scholar
  24. Z.-L. Wei and A. P. Kozikowski, “A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor δ,” Journal of Organic Chemistry, vol. 68, no. 23, pp. 9116–9118, 2003. View at Publisher · View at Google Scholar
  25. B. Båtshake and J. Sundelin, “The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap,” Biochemical and Biophysical Research Communications, vol. 227, no. 1, pp. 70–76, 1996. View at Publisher · View at Google Scholar
  26. R. M. Breyer, R. B. Emeson, J.-L. Tarng et al., “Alternative splicing generates multiple isoforms of a rabbit prostaglandin E2 receptor,” The Journal of Biological Chemistry, vol. 269, no. 8, pp. 6163–6169, 1994. View at Google Scholar
  27. K. Yu, W. Bayona, C. B. Kallen et al., “Differential activation of peroxisome proliferator-activated receptors by eicosanoids,” The Journal of Biological Chemistry, vol. 270, no. 41, pp. 23975–23983, 1995. View at Publisher · View at Google Scholar
  28. O. Nosjean and J. A. Boutin, “Natural ligands of PPARγ: are prostaglandin J2 derivatives really playing the part?” Cellular Signalling, vol. 14, no. 7, pp. 573–583, 2002. View at Publisher · View at Google Scholar
  29. L. Xu, C. Han, and T. Wu, “A novel positive feedback loop between peroxisome proliferator-activated receptor-δ and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth,” The Journal of Biological Chemistry, vol. 281, no. 45, pp. 33982–33996, 2006. View at Publisher · View at Google Scholar
  30. S. Han, J. D. Ritzenthaler, B. Wingerd, and J. Roman, “Activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer-binding protein β,” The Journal of Biological Chemistry, vol. 280, no. 39, pp. 33240–33249, 2005. View at Publisher · View at Google Scholar
  31. X. H. Liu, A. Kirschenbaum, M. Lu et al., “Prostaglandin E2 induces hypoxia-inducible factor-1a stabilization and nuclear localization in a human prostate cancer cell line,” The Journal of Biological Chemistry, vol. 277, no. 51, pp. 50081–50086, 2002. View at Publisher · View at Google Scholar
  32. D. Genini and C. V. Catapano, “Block of nuclear receptor ubiquitination: a mechanism of ligand-dependent control of peroxisome proliferator-activated receptor δ activity,” The Journal of Biological Chemistry, vol. 282, no. 16, pp. 11776–11785, 2007. View at Publisher · View at Google Scholar
  33. Y. Yu and K. Chadee, “Prostaglandin E2 stimulates IL-8 gene expression in human colonic epithelial cells by a posttranscriptional mechanism,” The Journal of Immunology, vol. 161, no. 7, pp. 3746–3752, 1998. View at Google Scholar
  34. M. Schwab, V. Reynders, S. Loitsch et al., “PPAR? is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells,” Carcinogenesis, vol. 29, no. 7, pp. 1407–1414, 2008. View at Publisher · View at Google Scholar
  35. L. Piqueras, A. R. Reynolds, K. M. Hodivala-Dilke et al., “Activation of PPARß/d induces endothelial cell proliferation and angiogenesis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 1, pp. 63–69, 2007. View at Publisher · View at Google Scholar
  36. L. Yang, Z.-G. Zhou, X.-L. Zheng et al., “RNA interference against peroxisome proliferator-activated receptor d gene promotes proliferation of human colorectal cancer cells,” Diseases of the Colon & Rectum, vol. 51, no. 3, pp. 318–326, 2008. View at Publisher · View at Google Scholar
  37. H. E. Hollingshead, R. L. Killins, M. G. Borland et al., “Peroxisome proliferator-activated receptor-ß/d (PPARß/d) ligands do not potentiate growth of human cancer cell lines,” Carcinogenesis, vol. 28, no. 12, pp. 2641–2649, 2007. View at Publisher · View at Google Scholar
  38. E. E. Girroir, H. E. Hollingshead, A. N. Billin et al., “Peroxisome proliferator-activated receptor-ß/d (PPARß/d) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines,” Toxicology, vol. 243, no. 1-2, pp. 236–243, 2008. View at Publisher · View at Google Scholar
  39. W. K. Sumanasekera, E. S. Tien, J. W. Davis II, R. Turpey, G. H. Perdew, and J. P. Vanden Heuvel, “Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-α (PPARα) and PPARβ activity,” Biochemistry, vol. 42, no. 36, pp. 10726–10735, 2003. View at Publisher · View at Google Scholar
  40. S. Chen, A.-C. Cheng, M.-S. Wang, and X. Peng, “Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein annexin V-FITC/PI double labeling,” World Journal of Gastroenterology, vol. 14, no. 14, pp. 2174–2178, 2008. View at Publisher · View at Google Scholar
  41. T. Cohen, O. Loutochin, M. Amin, J.-P. Capolicchio, P. Goodyer, and R. Jednak, “PAX2 is reactivated in urinary tract obstruction and partially protects collecting duct cells from programmed cell death,” American Journal of Physiology, vol. 292, no. 4, pp. F1267–F1273, 2007. View at Publisher · View at Google Scholar
  42. K.-H. Han, H.-Y. Kim, B. P. Croker et al., “Effects of ischemia-reperfusion injury on renal ammonia metabolism and the collecting duct,” American Journal of Physiology, vol. 293, no. 4, pp. F1342–F1354, 2007. View at Publisher · View at Google Scholar
  43. I. Shureiqi, W. Jiang, X. Zuo et al., “The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-d to induce apoptosis in colorectal cancer cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 17, pp. 9968–9973, 2003. View at Publisher · View at Google Scholar
  44. J.-Y. Liou, D. Ghelani, S. Yeh, and K. K. Wu, “Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3ε,” Cancer Research, vol. 67, no. 7, pp. 3185–3191, 2007. View at Publisher · View at Google Scholar
  45. J. M. López, M. A. Fernández, M. Piqué, and J. Gil, “Aspirin-induced apoptosis in Jurkat cells is not mediated by peroxisome proliferator-activated receptor delta,” Molecular and Cellular Biochemistry, vol. 266, no. 1-2, pp. 57–63, 2004. View at Publisher · View at Google Scholar
  46. M. I. Rauchman, S. K. Nigam, E. Delpire, and S. R. Gullans, “An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse,” American Journal of Physiology, vol. 265, no. 3, part 2, pp. F416–F424, 1993. View at Google Scholar
  47. P. D. Maroni, S. Koul, R. B. Meacham, P. S. Chandhoke, and H. K. Koul, “Effects of oxalate on IMCD cells: a line of mouse inner medullary collecting duct cells,” Annals of the New York Academy of Sciences, vol. 1030, pp. 144–149, 2004. View at Publisher · View at Google Scholar