MBX-102/JNJ39659100, a Novel Non-TZD Selective Partial PPAR- Agonist Lowers Triglyceride Independently of PPAR- Activation
Figure 3
Effect of
MBX-102 (100ā€‰mg/kg) and rosiglitazone (4ā€‰mg/kg) on fasting plasma glucose (a), triglycerides (b), FFA (c), and cholesterol (d) levels during the course of treatment of male ZDF rats.
Values are plotted as meanā€‰ā€‰ā€‰ā€‰SEM
(: , : , : versus ZDF vehicle; : ,
: , : versus MBX-102-treated group, 2-way ANOVA followed
by Bonferroni post tests). (e) Fasting plasma glucose, insulin, triglycerides, and FFA
levels on day 11. Values are plotted as mean percentage of vehicleā€‰ā€‰ā€‰ā€‰SEM
(NS: , : , : , : versus ZDF
vehicle, : versus MBX-102-treated group, 1-way ANOVA and Tukey's
multiple comparison test).