PPAR Research / 2009 / Article / Fig 1

Review Article

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs

Figure 1

Example reactions catalyzed by PPAR-regulated SULT and UGT enzymes. The upper panel shows the SULT2A1- and SULT2B1b-catalyzed 3-sulfonation of the prototype substrates, dehydroepiandrosterone and cholesterol, respectively. Human SULT2A1 is transcriptionally regulated by PPAR in human hepatocytes, while SULT2B1b is regulated by PPAR , PPAR and PPAR in keratinocytes. The lower panel shows the glucuronidation of bilirubin, -nitrophenol and hyodeoxycholic acid, which are prototype substrates for UGT1A1, UGT1A6, and UGT2B4, respectively. UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, and UGT2B4 have all been identified as PPAR target genes. PAPS, -phosphoadenosine- -phosphosulfate; UDP-GA, uridine- -diphospho- -D-glucuronic acid.

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