Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis

<table>LD between WG
associated variations of the 6p21.3 genomic region. HLA-DPB1 is modelled as a biallelic marker with the associated HLA-DPB1*0401 as one allele and all other
alleles joint into the other allelic category. LD is plotted as D′ and
intensity coded (darker shades corresponding to higher degree of LD). Both RXRB SNPs investigated in this study
(rs9277935 and rs2744537) are in high LD with HLA-DPB1 as well as with the markers analyzed by Heckmann et al. (2008): rs3117228 (3′ of HLA-DPB1)
and rs213208 (intronic SNP in RING1,
approx. 10 kb centromeric of RXRB).</table>

PPAR Research

fig2

Figure 2

Figure 2: Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis 