Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis

Table 2

Allele and haplotype frequencies.

Gene	SNP/haplotype	Allele	Frequency in controls	Frequency WG patients	P value	OR (95% CI)
RXRB	rs9277935	G	0.76	0.89	6.65  ×  10^-9	2.55 (1.86-3.56)
		T	0.24	0.11
	rs2072915	T	0.71	0.75	.157	1.20 (0.93-1.55)
		A	0.29	0.25
	rs2744537	T	0.73	0.57	6.63  ×  10^-9	0.49 (0.39-0.63)
		G	0.27	0.43
	rs1547387	C	0.87	0.85	.34	0.85 (0.62-1.18)
		G	0.13	0.15
RXRB^*	GTTC		0.24	0.40	1.15  ×  10^-9	2.11 (1.66-2.69)
	TTGC		0.19	0.07	9.73  ×  10^-10	0.32 (0.22-0.47)
	other		0.43	0.47	.157	1.18 (0.94-1.47)
PPARA	rs1800206	C	0.93	0.95	.076	1.40 (0.96-2.05)
		G	0.07	0.05
	rs6008259	G	0.80	0.83	.069	0.81 (0.65-1.02)
		A	0.20	0.17
PPARG	rs1801282	C	0.85	0.85	.74	0.96 (0.75-1.23)
		G	0.15	0.15
	rs3856806	C	0.86	0.85	.70	0.95 (0.75–1.22)
		T	0.14	0.15

OR: Odds ratio,CI: confidence interval,^*haplotype frequencies calculated from all four RXRB SNPs.