Cross-Talk between PPAR and Insulin Signaling and Modulation of Insulin Sensitivity
Figure 2
Insulin signaling pathway in adipose cells. Binding of insulin to its tyrosine kinase receptor engages a cascade of intracellular phosphorylation events, including activation of phosphatidylinositol-3-kinase and ERK-1/2, that promote multiple biological responses, including glucose uptake, lipid metabolism, survival, differentiation, and modulation of gene transcription.