Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPAR𝛾 and Identification of TUSC5 Coding Variants in Lean and Obese Humans

Table 2

Frequencies of rare and common coding variants in TUSC5 in lean and obese subjects.

Amino acid change (nucleotide shift)	Allele frequency
	Lean	Obese
P15S (C→T)	CC = 317	CC = 318
	CT = 58	CT = 61
	TT = 2	TT = 2
A18T(G→A)	GG = 365	GG = 368
	AG = 12	AG = 12
	AA = 0	AA = 1
S20F(C→T)	CC = 180	CC = 197
	CT = 172	CT = 151
	TT = 25	TT = 33
G57S(G→A)	GG = 210	GG = 217
	AG = 146	AG = 139
	AA = 21	AA = 25
I106T(T→C)	TT = 371	TT = 378
	CT = 6	CT = 3
	CC = 0	CC = 0
V109V(C→T)	CC = 376	CC = 381
	CT = 1	CT = 0
	TT = 0	TT = 0
A167A(C→T)	CC = 160	CC = 375
	CT = 0	CT = 1
	TT = 0	TT = 0