Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs

Table 3

The effects of PPARβ/δ agonists in EAE.

Agonists (Concentration)	Effects on immune cells	Effects on CNS cells	References
GW0742 (10 mg/kg/day)		Reduce astroglial and microglial inflammatory activation and IL-1β level in brain.; Increase the number of myelin-producing OLs.; Increase noggin protein expression in both OPCs and enriched astrocyte cultures.	Polak et al. [63], Simonini et al. [64]
GW501516 (25–100 ug/day)	Inhibit the expression of IFN-γ, IL-17, T-bet, IL-12 and IL-23.; Increase the expression of IL-4 and IL-10.		Kanakasabai et al. [65]
L165041 (25–100 ug/day)	Inhibit the expression of IFN-γ, IL-17, T-bet, IL-12 and IL-23.; Increase the expression of IL-4 and IL-10.		Kanakasabai et al. [65]