Effect of increasing doses of pioglitazone on acute gastric mucosal injury induced by aspirin-HCl in rats (a) The effect of pioglitazone on tissue-associated myeloperoxidase (MPO) activity (b) and TNF- content (c) induced by aspirin-HCl in the gastric mucosa. TNF- content and MPO activity in the gastric mucosa increased after aspirin administration. This increase in TNF- content and MPO activity was inhibited by pioglitazone treatment.
