Review Article

Gastrointestinal Cytoprotection by PPAR 𝛾 Ligands

Table 2

Cytoprotective properties of PPAR in experimental model of the intestinal inflammation.

Model ligandReferences

Ischemia/reperfusion injuryRosiglitazoneNakajima et al. [18]
PioglitazoneNaito et al. [25]
15d-PGJ2Cuzzocrea et al. [26]
DSS colitisTroglitazoneSu et al. [27]
RosiglitazoneSaubemann et al. [28]
PioglitazoneTakagi et al. [29], Schaefer et al. [30]
CLABassaganya-Riera et al. [31]
TNBS colitisTroglitazoneDesreumaux et al. [32]
RosiglitazoneSánchez-Hidalgo et al. [33]
PioglitazoneSchaefer et al. [30]
5-ASARousseaux et al. [34]
CD4+CD45RBhigh (transfer colitis model)CLABassaganya-Riera et al. [31]
IL-10 KO (genetic colitis model)RosiglitazoneLytle et al. [35]
SAMP1/YitFC (spontenouse colitis model)RosiglitazoneSugawara et al. [36]

DSS, dextran sodium sulphate; TNBS, 2,4,6-trinitrobenzene sulfonic acid; 15dPGJ2, 15-deoxy-D12,14-prostaglandin J2; CLA, conjugated linoleic acid; 5-ASA, 5-aminosalycilic acid; IL-10 KO, interleukin 10 knockout mice.