Review Article
Gastrointestinal Cytoprotection by PPAR Ligands
Table 2
Cytoprotective properties of PPAR
in experimental model of the intestinal inflammation.
| Model | ligand | References |
| Ischemia/reperfusion injury | Rosiglitazone | Nakajima et al. [18] | | Pioglitazone | Naito et al. [25] | | 15d-PGJ2 | Cuzzocrea et al. [26] | | | | DSS colitis | Troglitazone | Su et al. [27] | | Rosiglitazone | Saubemann et al. [28] | | Pioglitazone | Takagi et al. [29], Schaefer et al. [30] | | CLA | Bassaganya-Riera et al. [31] | | | | TNBS colitis | Troglitazone | Desreumaux et al. [32] | | Rosiglitazone | Sánchez-Hidalgo et al. [33] | | Pioglitazone | Schaefer et al. [30] | | 5-ASA | Rousseaux et al. [34] | | | | CD4+CD45RBhigh (transfer colitis model) | CLA | Bassaganya-Riera et al. [31] | IL-10 KO (genetic colitis model) | Rosiglitazone | Lytle et al. [35] | SAMP1/YitFC (spontenouse colitis model) | Rosiglitazone | Sugawara et al. [36] |
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DSS, dextran sodium sulphate; TNBS, 2,4,6-trinitrobenzene sulfonic acid; 15dPGJ2, 15-deoxy-D12,14-prostaglandin J2; CLA, conjugated linoleic acid; 5-ASA, 5-aminosalycilic acid; IL-10 KO, interleukin 10 knockout mice.
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