WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis
Figure 1
Effect of WY14643 on tissue damage and bone resorption. Gingivomucosal section from contra lateral side obtained from vehicle-treated rats (a) demonstrating no tissue damage. Inflammatory cells infiltration and edema was observed in gingivomucosal section from ligature-treated rats. (b) Significantly less edema and inflammatory cells infiltration was observed in gingivomucosal section from ligature-treated rats which have been treated with WY14643. (c) Moreover Masson’s trichrome stain was negative in gingivomucosal tissue sections taken from the contra lateral side (d) from vehicle when compared with gingivomucosal tissues sections of ligature-operated rats. (e) WY14643 treatment reduced the increase of collagen. (f) The alveolar bone from ligated rats demonstrated alveolar bone resorption. (g) WY14643 treatment suppressed alveolar pathology in the rat alveolar bone. (h) Figure is representative of at least 3 experiments performed on different experimental days.
