WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis

Figure 2

Effects of WY14643 treatment on NF-κB activation in periodontitis. Representative Western blots showing the effects of WY14643 on IκB-α degradation (a, a1) in the gingivomucosal tissues from ligature-operated rats. A representative blot of lysates (a) obtained from 5 animals per group is shown and densitometry analysis of all animals is reported. The results in panel (a1) are expressed as mean ± s.e.m. from 𝑛=5/6 gingivomucosal tissues for each group. ^∗𝑃<.01 versus nonligated. ^∘𝑃<.01 versus ligated.