Table 1: Some known coactivator and coactivator associated proteins that regulate PPAR function.

Coactivator proteinsEnzyme activityFunctionReferences

SRC-1/NCoA-1HATHistone acetylation[51, 52]
SRC-2/TIF2/GRIP1HATHistone acetylation[53]
SRC3/pCIP/AIB1HATHistone acetylation[54, 55]
CBP/p300HATHistone acetylation followed by recruitment of p160/SRCs[56]
MED1/TRAP220/PBPNoneAnchor for Mediator complex[57, 58]
PGC-1αNoneRecruit coactivator with HAT activities[59]
PGC-1β/PERCNoneRecruit coactivator with HAT activities[60]
PRIP/NCoA6NoneRecruit ASC complex[61, 62]
PRIC285HelicaseChromatin remodeling by histone displacement and nucleosomal sliding[63]
PRIC320/CHD9HelicaseChromatin remodeling by histone displacement and nucleosomal sliding[64]
SWI/SNFATPaseATP dependent mobilization of nucleosome[65, 66]
BAF60a/SMARCD1NoneRecruit SWI/SNF complex[67, 68]
BAF60c/SMARCD3NoneRecruit SWI/SNF complex[69]

Coactivator-associated proteins

PIMT/NCoA6IPMethyltransferaseMethylation of caps of snRNAs and snoRNAs[70]
CARM1/PRMT4MethyltransferasePotentiate SRCs by methylation of Histone H3[71]
CoAANoneRNA splicing[72]