Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease

Table 3

Serum profiles from PCK female mice—20 mg/kg BW Pioglitazone weeks 4–18.

	Normal range	Control diet 𝑛=12	Pio diet 𝑛=10	𝑃-value and significance
Na^+ mM	141–148	140±0.66	139±0.76	.442	NS
K^+ mM	4.3–5.9	4.92±1.82	4.6±0.53	.687	NS
Cl^− mM	101–108	99.7±0.54	100.5±0.72	.357	NS
Calcium mg/dl	9.6–11.2	10.3±0.14	9.6±0.36	.060	NS
BUN mg/dL	11–17	13.6±0.53	12.4±0.48	.118	NS
Creatinine mg/dL	0.4–0.7	0.33±0.01	0.34±0.03	.754	NS
Glucose mg/dL	120–186	162±6.00	146.5±4.59	.055	NS
Alkaline phos. U/L	65–117	315±11.18	355±26.67	.060	NS
Alanine aminotransferase U/L	25–45	62±3.55	70.0±6.71	.171	NS
Asparagine aminotransferase U/L	72–116	136±12.98	139.5±20.5	.302	NS
Bilirubin mg/dL	0.2–2	0.41±0.06	0.32±0.04	.281	NS
Total protein gr/dL	6.4–7.5	5.5±0.11	5.6±0.11	.486	NS
Albumin gr/dL	3.5–5.3	1.13±0.04	1.39±0.03	.0001	S

Values are given as means ± SEM. Control: PCK rats on the control diet; PIO: PCK rats on a diet containing 20 mg/kg body weight pioglitazone.
𝑛: number of animals 𝑃-values greater than  .05 were considered nonsignificant (NS).