PPAR Research / 2010 / Article / Tab 1

Research Article

Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha

Table 1

Effects of gestational administration (GD 1–18) of PFNA to wild type and PPARαKO mice on maternal weight and reproductive outcomes.

StrainDose (mg/kg/day)No. of pregnant Maternal Weight Gain GD1– (g)Maternal Weight GD (g)No. of uterine implantsTotal no. of Pups per litter (live dead)No. of live pups per litter % Litter loss Pregnancy rate (%)

WT014
0.8311
1.112
1.514
2.017

KO018
0.8313
1.114
1.59
2.016

Values are means SEM.
KO: PPARα knockout; WT: wild type; GD: gestational day.
Pregnancy verified by presence of uterine implantation sites.
Excludes adult females not pregnant or with full litter resorption.
Number of pups on day of birth at first observation.
Litter loss: uterine implants present but no pups (full litter resorption) or only dead pups (whole litter loss) at birth.
Pregnancy rate: (# pregnant / # plug +)*100.
,   .001 by Bonferroni’s test. by chi-square test for trend.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.