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PPAR Research
Volume 2010, Article ID 572405, 12 pages
Review Article

Role of PPAR 𝛼 in Hepatic Carbohydrate Metabolism

Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U.Leuven, Campus Gasthuisberg O/N2, 3000 Leuven, Belgium

Received 8 April 2010; Accepted 5 August 2010

Academic Editor: Elisabetta Mueller

Copyright © 2010 Annelies Peeters and Myriam Baes. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR 𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR 𝛼 in balancing glucose homeostasis as well. By using PPAR 𝛼 ligands and PPAR 𝛼 / mice, several crucial genes were shown to be regulated by PPAR 𝛼 in a direct or indirect way. We here review recent evidence that PPAR 𝛼 contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents.