PPAR in Obesity: Sex Difference and Estrogen Involvement
Figure 6
Inhibition of PPARα reporter gene expression ((a) and (b)) and coactivator recruitment (c) by 17 -estradiol. (a) NMu2Li cells were transiently transfected with expression plasmids for PPAR and PPRE3-TK-Luc reporter. Significantly different versus control group, Significantly different versus PPAR group @ Significantly different versus PPARα/Wy group, (b) NMu2Li cells were transiently transfected with expression plasmids for PPRE3-TK-Luc reporter and ER or ER : Significantly different versus control group, Significantly different versus respective ER group, (c) CV-1 cells were transiently transfected with expression plasmids for VP16-mPPAR GAL-CBP, reporter plasmid pFR-Luc, and VP16-hER or VP16-hER : Significantly different versus PPAR group, Significantly different versus PPAR/Wy group, Adapted from [32].
