PPAR in Obesity: Sex Difference and Estrogen Involvement
Figure 7
Mechanism of inhibitory effect of 17-estradiol on PPAR -mediated regulation of obesity. (a) Competition between PPAR and estrogen receptors (ERs) for coactivator binding. 17-estradiol-activated ERs can interfere with the PPRE binding of PPAR (b) Inhibition of PPAR actions on obesity by E. E impairs the ability of PPAR ligands to reduce body weight gain and adiposity in female ovariectomized (OVX) mice. FF: fenofibrate; RA: 9 cis-retinoic acid; RXR: retinoid X receptor. Adapted from [33].
