PPAR Research / 2010 / Article / Fig 7

Review Article

PPAR in Obesity: Sex Difference and Estrogen Involvement

Figure 7

Mechanism of inhibitory effect of 17 -estradiol on PPAR -mediated regulation of obesity. (a) Competition between PPAR and estrogen receptors (ERs) for coactivator binding. 17 -estradiol-activated ERs can interfere with the PPRE binding of PPAR (b) Inhibition of PPAR actions on obesity by E. E impairs the ability of PPAR ligands to reduce body weight gain and adiposity in female ovariectomized (OVX) mice. FF: fenofibrate; RA: 9 cis-retinoic acid; RXR: retinoid X receptor. Adapted from [33].
(a) Competition for coactivators
(b) Differential regulation of obesity

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