PPAR Research / 2010 / Article / Tab 1

Research Article

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

Table 1

List of target genes in different biological processes in liver. Genes regulated by in mouse are shown in lower case. Genes regulated in human and mouse are shown in CAPITAL BOLD. Genes regulated only in human are shown in CAPITAL, and genes with detected functional PPRE are shown in italic font.

Lipid metabolismLipid/hormone transportAdipor2 [24, 62], Cd36 [24, 6264], LEPR [24, 62], Slc27a1 [62, 6467], SLC27A2 [24, 62, 63, 68], SLC27A4 [24, 62]
Acyl-CoA formation/hydrolysis/ bindingAcot1 [24, 62, 69], Acot7 [62], ACOT12 [24, 62], ACSL1[24, 62, 7072], ACSL3 [24, 62], Acsl4 [24, 62, 63, 73], ACSL5 [24, 62, 63], ACSM3 [24, 62], Acss2 [62], FABP1[24, 62, 74, 75], Fabp2 [24, 62, 63], FABP3 [24, 62], Fabp4 [62, 68], Fabp5 [62]
Mitochondrial -oxidation/oxidative phosphorylationACAA2 [24, 62, 68], Acadl [24, 62, 70, 74, 76], ACADM[24, 55, 62, 70], ACADS [24, 54, 62, 70], ACADVL [24, 62, 63, 70], Acad8 [62], Acad9[62], Acad10 [62], Acot2 [24, 62, 69], Acot9 [62], Acot10 [62], CPT1A[24, 54, 55, 62, 7779], Cpt1b [24, 62], CPT2[24, 62, 70, 80], Crat [24, 62, 74], Dci [24, 62, 65, 68, 76], Decr1 [24, 62, 76, 81], ETFA [24], Etfb [24, 62], ETFDH [24, 62], HADHA [24, 62, 63, 68, 82], HADHB [24, 62, 63, 68], Hadh [24, 62, 68, 74, 76, 83], Hadh2 [62], Hibch [24, 62], SLC25A20[24, 62, 84], SLC22A5 [24, 62, 85, 86], TXNIP [24, 62], Ucp2 [24, 62, 8789], Ucp3 [62]
Ketogenesis/ketolysisAcat1[24, 62, 68], Bdh [62], FGF21[24, 62, 9092], Hmgcl [62], HMGCS2[24, 62, 9395]
Peroxisomal -oxidationABCD2 [24, 62, 96], ABCD3 [24, 62, 96], ACAA1A [24, 62, 68, 76], Acaa1b [24, 62], Acot3 [24, 62], Acot4 [24, 62], Acot5 [24, 62], Acot8 [62, 97], ACOX1[24, 55, 62, 68, 70, 98, 99], Crot [24, 62, 74], Decr2 [24, 62, 68, 100] ECH1 [24, 62, 63, 68], Ehhadh [24, 62, 101, 102], HACL1 [24], HSD17B4 [24, 62, 103, 104], Peci [24, 62, 65, 100], Pex11a [24]
Microsomal ( -hydroxylation)ALDH3A1[24], Aldh3a2 [24, 62, 105], ALDH9A1 [24], Cyp4a1 [74, 106109], Cyp4a3 [55, 74, 108], Cyp4a10 [24, 62, 68, 84, 106, 110], Cyp4a12a [24, 62, 65], Cyp4a14 [24, 62, 68, 110, 111], Cyp4f15 [24], Cyp4x1 [24]
LipogenesisAcaca [62], ACACB [62], AGPAT2 [62], Agpat3 [24, 62], Agpat5 [62], Agpat6 [62], Dgat1 [62, 112], ELOVL5 [62, 113, 114], ELOVL6 [24, 62, 113, 114], Elovl7 [62], FADS1 [24, 62, 113], Fads2 [62, 113, 115], Fasn [62, 112], GPAM [24, 62, 65], Hsd17b12 [62], Lpin2 [24, 56, 62], MLYCD [24, 62], Mogat1 [24, 62], MOD1[24, 62, 70, 116], Scd1 [24, 62, 117, 118], Scd2 [62, 68], Slc25a10 [62, 100], Srebf1 [24, 62, 119]
Lipases/lipid droplet proteinsADFP[24, 62, 120], Ces1 [62], Ces3 [24, 62], Cidea [24, 62, 121], CIDEC [24, 62, 121], Gos2 [24, 62, 122, 123], Lipa [24, 62], Lipe [24, 62, 68], Mgll [24, 62, 63, 68], Oxpat/Lsdp5 [24, 62, 124, 125], Plin1 [24], PNPLA2 [24, 62], S3-12 [24, 62]
Lipoprotein uptake and metabolismANGPTL4[24, 62, 126, 127], APOA1 [128133], APOA2 [24, 134], APOA5 [24, 135, 136], APOCIII [137139], LIPC [24, 62], Lipg [62], Lpl [62, 64, 65, 140], Lrp4 [24, 62], PCTP [24, 62], Pltp [62, 65, 141, 142], Mttp [24, 62, 143], VLDLR [24, 62]
Cholesterol/Bile transport and metabolismABCA1 [24, 62, 144], ABCB4 [24, 62, 94, 144], Abcb11 [62], Abcg5 [62, 144], Abcg8 [62, 144], Cav1 [24], CYP7A1 [24, 62, 145147], Cyp8b1 [62, 148], Cyp27a1 [145], FXR [62], LXR [144, 149], Npc1 [62], Rab9 [24, 62], Scarb2 [62], Slc10a1 [94], Slc10a2 [62, 150]

Other pathways Glucose/Glycerol transport and metabolismAQP3 [24, 62, 151], Aqp7 [62], Aqp9 [62, 151], Fbp2 [24, 62], G6PC [24], Gpd1 [24, 62, 151], Gpd2 [62, 151], GYK [24, 62, 151], Gys-2 [152], Ldha [62], Pcx [62], PCK1 [24], Pdk1 [24], PDK4 [24, 62, 153, 154]
BiotransformationAKR1B10 [24], AKR1C3 [24], CYP1A2 [24], Cyp2a5 [110], CYP2B6 [24], CYP2C8 [24], CYP2C9 [24], Cyp2c11 [155], Cyp2c12 [155], Cyp2c29 [110], CYP2J2 [24], CYP3A5 [24], CYP3A7 [24], CYP3A11 [24, 110], Cyp3a43 [24], EPHX2 [24, 156], Gsta3 [157], MGST3 [24], UGT1A9[158]
Amino Acid metabolismABAT [24, 159], Acmsd [159], AGXT2 [24, 160], Arg1 [160], ASL [24, 160], Ass1 [160], CBS [24, 159], CPS-1 [24, 160], Cth [159], Got1 [160], Got2 [62, 64, 160, 161], Gls [160], GLS2 [159], GPT [24, 159], Hal [159], Hpd [159], OAT [24, 159], ODC1 [24, 62, 159], OTC [24, 62, 160], PAH [24, 159], PSAT1 [24, 62, 159], Tat [159, 162]
InflammationApcs [163], Birc3 [163], Cebpb [164], Cd68 [24, 165], Crp [24, 163], Cxcl10/IP10 [165], FGB [24, 155, 166, 167], Emr1 (F4/80) [156], Icam-1 [24, 165], Ifi47 [24, 163], Igtp [163], Nfkbia [168170], Il-1 [165], Il-1r1 [111], Il1rn [163], Il1rap [163], Il-6 [111, 171], Il-6ra [111, 163], Il18 [163], Lcn2 [163, 165], Lifr [163], Ccl2 [165], Ccl3 [165], Mt1 [24, 163], Mt2 [163, 165], Orm2 [163], Orm3 [24, 163], Nfkb1 [24, 164], Pla1a [24, 163], Saa2 [163], Saa4 [24, 163], Stat1 [165], Stat2 [163], Stat3 [163], Steap4 [24, 163], Stress induced protein [163], Tnfα [165], Traf2 [163], Vcam-1 [24, 165]

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