Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPAR𝛼

Figure 2

Hematoxylin-eosin-stained colon sections of Il10^−/− and C57 mice. (a) Colon section (×20) from a non-inflamed C57 mouse at 12 weeks of age. (b) Colon section (×100) from an Il10^−/− mouse at 7 weeks of age with no inflammation. (c) Moderate to severe inflamed colon section (×40) from an Il10^−/− mouse at 12 weeks of age. Lesions involve most of the colon section with mainly monocyte and neutrophil infiltration (←), crypt abscesses, and loss of crypt and goblet cells (◂).

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