Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPAR𝛼

Table 2

Time of onset and incidence of colon inflammation in Il10^−/− mice.

Weeks of age	7	8.5	10	12	14
Number of mice sampled
Il10^−/− mice (total 28^1)	5	6	6	6	5
C57 mice (total 30)	6	6	6	6	6
Number of mice with inflamed colon^2
Il10^−/− mice	2	4	6	6	4
C57 mice	0	0	0	0	0
Incidence of colon inflammation (%)
Il10^−/− mice	40	67	100	100	80
C57 mice	0	0	0	0	0

¹Two Il10^−/− mice died during the study due to unknown causes. ²Mice were regarded as inflamed when their total colon histological injury score (HIS) was >3 (4–6 moderate inflammation, ≥7 severe inflammation). All C57 mice had a total colon HIS ≤ 3.