Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPAR𝛼

Table 5

Categories of genes with expression increase of 2-fold or more in Il10^−/− mice compared to C57 mice at 7 weeks of age using EASE.

System	Gene category	EASE score	FDR
GO Cellular Component	spindle cell	3.91E-04	<0.001
GO Molecular Function	MHC class II receptor activity	1.25E-03	<0.001
GO Biological Process	antigen processing, exogenous antigen via MHC class II	1.37E-03	<0.001
GO Biological Process	antigen presentation, exogenous antigen	1.37E-03	<0.001
GO Biological Process	alcohol metabolism	2.27E-03	<0.001
GO Biological Process	glucose metabolism	4.37E-03	<0.001
GO Biological Process	main pathways of carbohydrate metabolism	6.39E-03	<0.001
GO Biological Process	protein targeting	7.76E-03	<0.001
GO Biological Process	steroid biosynthesis	1.02E-02	<0.001
GO Biological Process	steroid metabolism	1.09E-02	<0.001
GO Biological Process	sterol biosynthesis	1.29E-02	<0.001
GO Cellular Component	microtubule cytoskeleton	1.75E-02	<0.001
GO Biological Process	sterol metabolism	1.82E-02	<0.001
GO Biological Process	carbohydrate metabolism	1.89E-02	<0.001
GO Biological Process	hexose metabolism	1.92E-02	<0.001
GO Molecular Function	oxidoreductase activity, acting on CH-OH group of donors	1.96E-02	<0.001
GO Biological Process	energy derivation by oxidation of organic compounds	2.47E-02	<0.001
GO Biological Process	catabolism	2.54E-02	<0.001
GO Cellular Component	soluble fraction	2.82E-02	<0.001
GO Molecular Function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.92E-02	<0.001
GO Biological Process	monosaccharide metabolism	3.13E-02	<0.001