Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPAR𝛼

Table 6

Proteome and transcriptome network analysis for expression profiles from the colon of 7- and 12-week-old Il10^−/− mice compared to C57 mice using IPA.

Network	Top functional categories
Il10^−/−versus C57 mice at 7 weeks of age
Transcriptome 1	Cancer, Dermatological disease and conditions, Endocrine system development and function
Transcriptome 2	Cardiovascular system development and function, Cancer, Tissue development
Transcriptome 3	Cancer, Cell death, Reproductive system disease
Transcriptome 4	Cell cycle, Cell-mediated immune response, Cancer
Transcriptome 5	Cellular growth and proliferation, Hematological system development and function, Hematopoiesis
Il10^−/−versus C57 mice at 12 weeks of age
Proteome 1	Tissue morphology, Cellular movement, Cell-mediated immune response
Proteome 2	Cell death, Hematological disease, Immunological disease
Proteome 3	Cancer, Tumour morphology, Cellular development
Proteome 4	Cardiovascular disease, Gene expression, Molecular transport
Transcriptome 1	Antigen presentation, Cell morphology, Cell-to-cell signaling and interaction
Transcriptome 2	Cancer, Gastrointestinal disease, Dermatological diseases and conditions
Transcriptome 3	Lipid metabolism, Small molecule biochemistry, Carbohydrate metabolism
Transcriptome 4	Inflammatory disease, Cell-to-cell signaling and interaction, Cell-mediated immune response

The top 3 biological functions for the most significant transcriptomic and proteomic networks (representing subsets of focus genes and proteins highly associated with those functions) are shown.