Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPAR𝛼

Table 8

Categories of genes with expression increase of 2-fold or more in Il10^−/−mice compared to C57 mice at 12 weeks of age using EASE.

System	Gene category	EASE score	FDR
GO Biological Process	defence response	5.92E-14	<0.001
GO Biological Process	response to biotic stimulus	7.39E-14	<0.001
GO Biological Process	response to external stimulus	1.38E-12	<0.001
GO Biological Process	immune response	4.06E-12	<0.001
GO Biological Process	antigen presentation	4.14E-07	<0.001
GO Biological Process	antigen processing	4.52E-06	<0.001
GO Molecular Function	defence/immunity protein activity	6.14E-06	<0.001
GO Molecular Function	MHC class I receptor activity	2.67E-05	<0.001
GO Biological Process	response to pest/pathogen/parasite	1.43E-04	<0.001
GO Biological Process	physiological process	1.47E-04	<0.001
GO Molecular Function	antigen binding	2.31E-04	<0.001
GO Biological Process	response to stress	2.49E-04	<0.001
GO Biological Process	antigen presentation, endogenous antigen	1.21E-03	<0.001
GO Molecular Function	MHC class II receptor activity	1.56E-03	<0.001
GO Biological Process	antigen processing, exogenous antigen via MHC class II	1.67E-03	<0.001
GO Biological Process	antigen presentation, exogenous antigen	1.67E-03	<0.001
GO Cellular Component	extracellular space	1.75E-03	<0.001
GO Biological Process	protein targeting	2.57E-03	<0.001
GO Biological Process	humoral immune response	2.97E-03	<0.001
GO Cellular Component	plasma membrane	7.23E-03	<0.001
GO Biological Process	antigen processing, endogenous antigen via MHC class I	8.44E-03	<0.001
GO Biological Process	response to wounding	1.07E-02	<0.001
GO Molecular Function	oxidoreductase activity, acting on CH-OH group of donors	1.15E-02	<0.001
GO Molecular Function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.71E-02	<0.001
GO Molecular Function	hydrolase activity	1.86E-02	<0.001
GO Biological Process	collagen catabolism	2.07E-02	<0.001
GO Biological Process	posttranslational membrane targeting	2.18E-02	<0.001
GO Biological Process	innate immune response	2.22E-02	<0.001
GO Cellular Component	vesicular fraction	2.51E-02	<0.001
GO Biological Process	response to chemical substance	3.06E-02	<0.001
GO Biological Process	inflammatory response	3.06E-02	<0.001