Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice

Figure 3

Two-dimensional representation of differentially expressed genes involved in IAT mitochondrial and peroxisomal functions. Ratio for differentially expressed genes in db/+ and RSG-treated db/db versus untreated db/db were plotted. Each coloured box represents differential expression ratio ranging from bright green (lowest) to bright red (highest). Missing value are in grey when P-value ≥  .001. Genes involved in mitochondrial transport of FA, in mitochondrial and peroxisomal 𝛽-oxidation and citrate cycle and in oxidative phosphorylation were shown.