Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice
Figure 7
Generation of PLS models to predict physiological changes from multivariate gene expression data. Results show the correlations between the actual liver weight (a), the liver trioleate concentrations (b), the blood glucose level (c) and the predicted parameters from the PLS model. The normalised logs (ratio) of genes involved in glucose and lipid metabolism were used as predictor variables (X) and physiological parameters as response variables (Y). All variables were centred and scaled to unit variance, before the PLS analysis was performed.
