PPAR Research

Research Article

Effects of the PPAR Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism

Table 2

Clinical chemistry data for male Harlan Sprague Dawley rats, B6C3F1 mice, and Syrian hamsters following exposure to gemfibrozil in feed for 34 days (special study) or 14 weeks (core study)a.
Rats0 ppm10 ppm100 ppm1000 ppm8000 ppm16000 ppm
 Day 34
 Week 14
ALT (IU/L)
 Day 34
 Week 14
SDH (IU/L)
 Day 34
 Week 14
ALP (IU/L)
 Day 34
 Week 14
Bile Salts ( mol/L)
 Day 34
 Week 14
Cholesterol (mg/dL)
 Day 34
 Week 14
Triglycerides (mg/dL)
 Day 34
 Week 14
Mice
Cholesterol (mg/dL)
 Day 34
 Week 14
Triglycerides (mg/dL)
 Day 34
 Week 14
Hamsters
ALT (IU/L)
 Day 34
 Week 14
SDH (IU/L)
 Day 34
 Week 14
ALP (IU/L)
 Day 34
 Week 14
Bile Salt ( mol/L)
 Day 34
 Week 14
Cholesterol (mg/dL)
 Day 34
 Week 14
Triglycerides (mg/dL)
 Day 34
 Week 14
*Significantly different ( ) from the control group by Dunn’s or Shirley’s test; ** ; error, statistical tests were performed on unrounded data; ; ;