Effects of the PPAR𝛼 Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism

Table 4

Relative liver weights in male special study Harlan Sprague Dawley rats, B6C3F1 mice, and Syrian hamsters following exposure to gemfibrozil in feed for 6 days, 34 days, or 13 weeks^a,b.

Rats	0ppm	10ppm	100ppm	1000ppm	8000ppm	16000ppm
Day 6	40.720±1.154	43.574±0.995	49.162±1.292^∗∗	55.277±1.702^∗∗	59.642±1.612^∗∗	54.037±0.718^∗∗
Day 34	36.76±0.540	37.50±0.583	45.444±0.693^∗∗	53.942±1.449^∗∗	68.603±2.391^∗∗	75.290±1.296^∗∗
Week 13	31.627±1.168	33.179±0.357	39.391±0.866^∗∗	48.137±0.523^∗∗	74.370±1.212^∗∗	86.782±1.678^∗∗
Mice	0ppm	10ppm	100ppm	1000ppm	4000ppm	8000ppm
Day 6	51.954±0.788	50.291±1.108	51.703±2.524	54.417±1.465	64.524±1.391^∗∗	76.920±0.441^∗∗
Day 34	41.768±1.153	45.376±0.687^∗∗	47.546±0.742^∗∗	51.955±0.327^∗∗	63.724±1.036^∗∗	72.806±0.749^∗∗
Week 13	41.152±0.390	42.606±0.862	41.689±0.737	43.299±1.153	60.370±01.303^∗∗	71.208±1.235^∗∗
Hamsters	0ppm	100ppm	1000ppm	6000ppm	12000ppm	24000ppm
Day 6	5.447±0.286	5.119±0.195	5.463±0.384	5.448±0.219	5.364±0.157	5.214±0.272
Day 34	4.238±0.196	4.292±0.093	4.295±0.076	4.629±0.195	4.723±0.126^∗	5.341±0.106^∗∗
Week 13	3.867±0.086	3.718±0.121	3.864±0.122	3.940±0.082	4.586±0.067^∗∗	5.072±0.157^∗∗

^∗Significantly different (𝑃≤.05) from the control group by Dunnett’s or Williams’ test; ^∗∗𝑃≤.01; ^aData are given as mg organ weight/g body weight (mean ± standard error); ^b𝑛=5.