Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α

Table 1

Characteristics of the studies used in the rat and mouse liver microarray analysis.

Species	Reference	GEO Accession number	Strain	Dose frequency	Chemical and (Dose)^1	Time of treatment	Vehicle	Array type	Number of biological replicates	Total number of  .cel files
Rat	Martin et al., 2007 [22]	GSE14712	SD (Wistar)	Once daily	PFOA (20) and PFOS (10)	3 days	15% Alkamuls	RAE230 2.0	3	9
Rat	Ellinger-Ziegelbauer et al., 2005 [28]	GSE14712	SD (Wistar)	Once daily	WY (60)	1 day, 3 days, 7 days	Carboxymethylcellulose	RAE230A	3	12
Rat	Jolly et al., 2005 [21]	GSE2303	SD	Once	DEHP (20,000); Valproic acid (2000)	4, 24, 48 hrs	Distilled water	Rat U34A	3–5	16 (DEHP); 15 (VPA)
Rat	Jolly et al., 2005 [21]	GSE2303	SD	Once	Clofibrate (1000)	4, 24, 48 hrs	0.9% saline	Rat U34A	3–5	16
Rat	Nelson et al., 2006 [29]	GSE14712	SD	Once daily	PB (100) and PCN (100)	6 hrs, 1 day, 5 days	1% Tween-80 in 0.5% aqueous methylcellulose	RAE230 2.0	4	36
Mouse	Sanderson et al., 2008 [23]	GSE8292,; GSE8295	SV129 and PPARα-null	Once daily	WY^2	6 hrs, 5 days		Mouse 430_2	3–5 (6 hrs); 4 (5 days)	17 (6 hrs); 16 (5 days)
Mouse	Currie et al., 2005 [30]	Not submitted	C57BL/6J	Once daily	DEHP (1150)	2, 8, 24 hrs, 3 days	Corn oil	Mouse 430_2	3	24
Mouse	Rosen et al., 2008 [24]	GSE9786	SV129 and PPARα-null	Once daily	PFOA (3)	7 days	Distilled water	Mouse 430_2	4	16
Mouse	Sanderson et al., 2008 [23]	GSE8295; GSE8396	SV129 and PPARα-null	Once	Fenofibrate^2	6 hrs		430_2	4	16

All exposure experiments were conducted on male rats or mice by gavage.
¹All doses are in mg/kg/day.
Abbreviations: DEHP: di-2-ethylhexyl phthalate; WY: WY-14,643; PFOA: perfluorooctanoic acid; PFOS: perfluorooctane sulfonate; SD: Sprague-Dawley; PB: phenobarbital; PCN: pregnenolone-16alpha-carbonitrile.
²400 μL of a 10 mg/mL solution/day.