Gene Expression Profiling in Wild-Type and PPAR𝛼-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR𝛼-Independent Effects

Figure 3

Functional categories of genes modified by PFOS in WT and Null mice. In WT mice, PFOS altered the expression of genes related to a variety of PPAR$\alpha$-regulated functions including lipid metabolism, peroxisome biogenesis, proteasome activation, and the inflammatory response. Genes affected in both WT and Null mice consisted of transcripts related to lipid metabolism, inflammation, and xenobiotic metabolism. Several categories of genes were uniquely regulated by PFOS in Null mice including up-regulation of genes in the cholesterol biosynthesis pathway as well as modest down-regulation of genes associated with oxidative phosphorylation and ribosome biogenesis. Red or green corresponds to average up- or down- regulation, respectively.