Gene Expression Profiling in Wild-Type and PPAR𝛼-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR𝛼-Independent Effects

Table 10

Average fold change for genes related to ribosome biogenesis following a seven-day exposure to Wy-14,64$3^1$, PFOA¹, or PFOS in wild-type and PPAR$\alpha$-null male mice.

					WT			Null
Symbol	Gene name	Entrez no.	Wy14,643 50 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg
MRPL12	mitochondrial; ribosomal protein L12	56282	−1.16	1.25	1.07	1.14*	−1.16	−1.18	−1.12*
MRPL13	mitochondrial; ribosomal protein L13	68537	1.32	1.33	1.12	1.35*	1.01	−1.21	−1.42**
MRPL17	mitochondrial; ribosomal protein L17	27397	1.68	1.76	1.10	1.43**	1.13	−1.13	1.09
MRPL23	mitochondrial; ribosomal protein L23	19935	−1.14	−1.04	−1.00	1.10	1.09	−1.38	−1.20*
MRPL33	mitochondrial; ribosomal protein L33	66845	1.22	1.26	1.07	1.05	1.04	−1.29	−1.28**
MRPS12	mitochondrial; ribosomal protein S12	24030	−1.24	1.18	1.05	1.12	1.02	−1.27	−1.15
MRPS18A	mitochondrial; ribosomal protein S18A	68565	−1.46	1.34	1.04	1.28*	1.60	−1.19	−1.06
RPL10	ribosomal protein; L10	110954	−1.15	−1.21	1.02	1.03	1.07	−1.10	−1.02
RPL10A	ribosomal protein; L10A	19896	−1.11	1.10	1.03	1.05	1.00	−1.07	1.01
RPL11	ribosomal protein; L11	67025	1.14	1.12	1.10	1.11*	1.15	−1.15	−1.09
RPL12	ribosomal protein; L12	269261	1.01	1.37	1.08	1.15*	1.11	−1.08	1.05
RPL13A	ribosomal protein; L13a	22121	−1.14	1.03	1.07	1.12*	−1.17	−1.15	−1.10
RPL14	ribosomal protein; L14	67115	−1.28	−1.06	1.15	1.23**	−1.13	−1.18	−1.22*
RPL17	ribosomal protein; L17	319195	−1.27	1.15	1.03	1.12	−1.52	−1.10	−1.09
RPL18	ribosomal protein; L18	19899	−1.11	1.28	1.04	1.07*	1.19	−1.27	−1.09*
RPL18A	ribosomal protein; L18a	76808	1.65	−1.37	1.04	1.11*	1.08	−1.15	−1.02
RPL19	ribosomal protein; L19	19921	1.22	1.23	1.01	1.05	1.07	−1.11	−1.03
RPL21	ribosomal protein; L21	19933	2.00	1.55	1.03	1.09	1.18	−1.20	−1.18
RPL22	ribosomal protein; L22	19934	1.17	1.45	1.06	1.29**	1.08	−1.25	−1.14*
RPL23	ribosomal protein; L23	65019	−1.07	1.35	1.06	1.06	1.22	−1.24	−1.16
RPL24	ribosomal protein; L24	68193	−1.13	1.07	1.06	1.09*	−1.00	−1.19	−1.11*
RPL26	ribosomal protein; L26	19941	1.04	1.22	1.03	1.03	1.07	−1.22	−1.18**
RPL27	ribosomal protein; L27	19942	1.04	−1.01	1.08	1.38**	1.06	−1.25	−1.40*
RPL27A	ribosomal protein; L27a	26451	−1.07	1.07	−1.00	1.17	1.26	−1.17	−1.09
RPL28	ribosomal protein; L28	19943	1.29	1.04	1.01	1.11*	1.67	−1.22	−1.10
RPL29	ribosomal protein; L29	19944	1.16	−1.30	1.04	1.09	1.08	−1.23	−1.17
RPL3	ribosomal protein; L3	27367	−1.00	−1.14	1.01	1.09	−1.01	−1.03	1.06
RPL30	ribosomal protein; L30	19946	−1.15	−1.07	1.02	−1.21	−1.04	−1.29	−1.23**
RPL31	ribosomal protein; L31	114641	1.11	1.37	1.09	1.05	1.29	−1.18	−1.12*
RPL32	ribosomal protein; L32	19951	1.06	1.11	1.02	1.12*	1.08	−1.16	−1.03
RPL34	ribosomal protein; L34	68436	−1.26	1.16	−1.07	1.05	−1.04	−1.22	−1.31**
RPL35	ribosomal protein; L35	66489	−1.03	1.15	1.13	1.26**	1.04	−1.17	−1.11
RPL36	ribosomal protein; L36	54217	−1.07	1.12	1.09	1.23*	1.07	−1.27	−1.20*
RPL37	ribosomal protein; L37	67281	−1.16	−1.18	1.04	1.27*	1.17	−1.19	−1.10**
RPL37A	ribosomal protein; L37a	19981	−1.15	−1.09	1.03	1.16	−1.12	−1.22	−1.19*
RPL38	ribosomal protein; L38	67671	−1.17	1.14	−1.01	1.06	−1.03	−1.18	−1.10
RPL39	ribosomal protein; L39	67248	1.04	1.02	1.06	1.13*	1.07	−1.18	−1.16**
RPL4	ribosomal protein; L4	67891	1.16	1.43	1.03	1.03	1.32	1.03	1.04
RPL41	ribosomal protein; L41	67945	−1.06	1.14	1.05	1.06	−1.13	−1.20	−1.26*
RPL5	ribosomal protein; L5	19983	−1.21	1.02	1.24	1.09*	−1.05	−1.05	−1.11
RPL6	ribosomal protein; L6	19988	1.01	−1.08	1.00	1.05	1.15	−1.05	1.03
RPL7A	ribosomal protein; L7a	27176	−1.02	−1.11	1.01	1.01	−1.02	−1.07	1.01
RPL9	ribosomal protein; L9	20005	−1.35	−1.08	1.03	1.07	−1.11	−1.19	−1.12*
RPS10	ribosomal protein; S10	67097	−1.02	1.02	1.05	1.07	1.00	−1.17	−1.12*
RPS11	ribosomal protein; S11	27207	1.05	−1.74	−1.01	1.11	1.06	−1.24	−1.14*
RPS12	ribosomal protein; S12	20042	1.16	1.22	1.11	1.19	1.22	−1.21	−1.12
RPS13	ribosomal protein; S13	68052	−1.03	1.10	1.07	1.22*	1.11	−1.27	−1.22*
RPS14	ribosomal protein; S14	20044	−1.03	1.19	1.05	1.11*	1.01	−1.17	−1.11**
RPS15A	ribosomal protein; S15a	267019	−1.05	1.05	1.02	1.12	1.02	−1.14	−1.20
RPS16	ribosomal protein; S16	20055	−1.09	1.05	1.05	1.07	−1.02	−1.12	−1.07
RPS17	ribosomal protein; S17	20068	1.00	1.16	1.04	−1.19*	1.01	−1.19	−1.15*
RPS19	ribosomal protein; S19	20085	−1.07	1.23	1.08	1.19**	−1.00	−1.14	−1.05
RPS2	ribosomal protein; S2	16898	−1.09	1.02	1.04	1.02	−1.16	−1.03	1.04
RPS20	ribosomal protein; S20	67427	−1.40	1.21	1.04	1.15	1.25	−1.11	−1.13
RPS21	ribosomal protein; S21	66481	1.11	−1.32	1.15	1.38	1.39	−1.32	−1.25**
RPS23	ribosomal protein; S23	66475	1.01	1.04	−1.00	1.04	1.09	−1.21	−1.10*
RPS24	ribosomal protein; S24	20088	1.58	1.62	1.11	−1.29*	1.75	−1.16	−1.19**
RPS25	ribosomal protein; S25	75617	−1.23	1.01	1.09	1.13*	−1.02	−1.30	−1.17*
RPS26	ribosomal protein; S26	27370	1.32	1.30	1.04	1.16*	1.14	−1.20	−1.08
RPS27A	ribosomal protein; S27a	78294	1.05	−1.05	−1.00	1.02	1.09	−1.08	−1.05
RPS27L	ribosomal protein; S27-like	67941	1.72	1.28	1.07	1.14*	1.19	−1.18	−1.17*
RPS28	ribosomal protein; S28	54127	−1.19	−1.03	1.03	1.06	−1.05	−1.28	−1.17*
RPS29	ribosomal protein; S29	20090	−1.26	−1.05	−1.02	1.01	−1.03	−1.19	−1.20**
RPS3	ribosomal protein; S3	27050	−1.04	1.29	1.03	1.20*	−2.88	−1.11	−1.06
RPS3A	ribosomal protein; S3A	544977	−1.18	−1.07	1.02	−1.01	−1.05	−1.10	−1.03
RPS5	ribosomal protein; S5	20103	−1.16	1.18	1.06	1.09*	−1.02	−1.13	−1.00
RPS6	ribosomal protein; S6	20104	−1.20	−1.02	−1.20	1.06	−1.02	−1.14	−1.06*
RPS8	ribosomal protein; S8	20116	1.19	−1.05	1.07	1.13*	1.04	−1.29	−1.13
RPS9	ribosomal protein; S9	76846	−1.39	1.30	1.05	1.07	1.05	−1.08	−1.04

¹From Rosen et al. (2008), *Significantly different than control ($P\le .03$),
**Significantly different from control ($P\le .0025$).