Table 4: Average fold change for genes related to proteasome biogenesis in wild-type and PPARα-null male mice following a seven-day exposure to Wy-14,6431, PFOA1, or PFOS.

WTNull
SymbolGene nameEntrez no.Wy14,643 50 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kg

PSMA1proteasome unit,
alpha type, 1
264401.611.381.151.31*1.17−1.29−1.34
PSMA2proteasome unit,
alpha type, 2
19166−1.46−1.151.091.23**−1.34−1.20−1.07
PSMA3proteasome unit,
alpha type, 3
191671.331.221.121.141.28−1.13−1.17
PSMA4proteasome unit,
alpha type, 4
264411.191.321.101.19*1.01−1.041.05
PSMA5proteasome unit,
alpha type, 5
264421.671.591.121.26**1.15−1.121.09
PSMA6proteasome unit,
alpha type, 6
264431.201.291.141.24**1.06−1.14−1.06
PSMA7proteasome unit,
alpha type, 7
264441.471.601.231.53**1.23−1.121.11
PSMB1proteasome unit,
beta type, 1
191701.091.291.071.28*1.04−1.171.13*
PSMB10proteasome unit,
beta type, 10
19171−1.42−1.48−1.25−1.19−1.57−1.14−1.21**
PSMB2proteasome unit,
beta type, 2
264451.331.481.051.31**1.02−1.201.05
PSMB3proteasome unit,
beta type, 3
264461.221.471.211.36**1.04−1.37−1.20
PSMB4proteasome unit,
beta type, 4
191721.591.651.271.55**1.22−1.121.09
PSMB5proteasome unit,
beta type, 5
191731.341.741.041.24**1.02−1.151.03
PSMB6proteasome unit,
beta type, 6
191751.541.831.081.24*1.19−1.23−1.09
PSMB7proteasome unit,
beta type, 7
191771.461.331.071.15**1.13−1.17−1.09
PSMB8proteasome unit,
beta type, 8
16913−1.61−2.00−1.44−1.51−1.38−1.23−1.45**
PSMB9proteasome unit,
beta type, 9
169121.24−1.12−1.31−1.09−1.10−1.11−1.30**
PSMC1proteasome 26S unit,
ATPase, 1
191791.441.001.191.15*1.11−1.061.01
PSMC6proteasome 26S unit,
ATPase, 6
670891.181.211.09−1.021.071.14−1.16
PSMD1proteasome 26S unit,
non-ATPase, 1
702471.201.221.151.25**1.091.031.15
PSMD11proteasome 26S unit,
non-ATPase, 11
690771.561.381.091.26*−1.171.161.32
PSMD12proteasome 26S unit,
non-ATPase, 12
669971.341.271.101.141.20−1.031.04
PSMD13proteasome 26S unit,
non-ATPase, 13
239971.211.381.141.26*−1.03−1.38−1.42**
PSMD14proteasome 26S unit,
non-ATPase, 14
59029−1.39−1.421.171.31*1.311.011.17
PSMD2proteasome 26S unit,
non-ATPase, 2
217621.341.321.141.24*1.101.091.30**
PSMD3proteasome 26S unit,
non-ATPase, 3
22123−1.35−1.191.171.29*1.081.041.22*
PSMD4proteasome 26S unit,
non-ATPase, 4
191851.311.921.191.38**1.03−1.071.17*
PSMD6proteasome 26S unit,
non-ATPase, 6
664131.171.331.101.14*1.07−1.061.04
PSMD7proteasome 26S unit,
non-ATPase, 7
174631.131.271.131.24*1.02−1.19−1.22*
PSMD8proteasome 26S unit,
non-ATPase, 8
572961.681.241.031.30**1.16−1.15−1.00
PSME1proteasome activator
unit 1
191861.22−1.00−1.051.32**1.27−1.10−1.09
VCPvalosin−containing
protein
2695231.401.491.041.121.071.131.21**

1From Rosen et al. (2008),
*Significantly different than control (P.03),
**Significantly different than control (P.0025).