Table 4: Average fold change for genes related to proteasome biogenesis in wild-type and PPAR$\alpha$-null male mice following a seven-day exposure to Wy-14,64$3^1$, PFOA1, or PFOS.

WT Null Symbol Gene name Entrez no. Wy14,643 50 mg/kg PFOA 3 mg/kg PFOS 3 mg/kg PFOS 10 mg/kg PFOA 3 mg/kg PFOS 3 mg/kg PFOS 10 mg/kg PSMA1 proteasome unit, alpha type, 1 26440 1.61 1.38 1.15 1.31* 1.17 −1.29 −1.34 PSMA2 proteasome unit, alpha type, 2 19166 −1.46 −1.15 1.09 1.23** −1.34 −1.20 −1.07 PSMA3 proteasome unit, alpha type, 3 19167 1.33 1.22 1.12 1.14 1.28 −1.13 −1.17 PSMA4 proteasome unit, alpha type, 4 26441 1.19 1.32 1.10 1.19* 1.01 −1.04 1.05 PSMA5 proteasome unit, alpha type, 5 26442 1.67 1.59 1.12 1.26** 1.15 −1.12 1.09 PSMA6 proteasome unit, alpha type, 6 26443 1.20 1.29 1.14 1.24** 1.06 −1.14 −1.06 PSMA7 proteasome unit, alpha type, 7 26444 1.47 1.60 1.23 1.53** 1.23 −1.12 1.11 PSMB1 proteasome unit, beta type, 1 19170 1.09 1.29 1.07 1.28* 1.04 −1.17 1.13* PSMB10 proteasome unit, beta type, 10 19171 −1.42 −1.48 −1.25 −1.19 −1.57 −1.14 −1.21** PSMB2 proteasome unit, beta type, 2 26445 1.33 1.48 1.05 1.31** 1.02 −1.20 1.05 PSMB3 proteasome unit, beta type, 3 26446 1.22 1.47 1.21 1.36** 1.04 −1.37 −1.20 PSMB4 proteasome unit, beta type, 4 19172 1.59 1.65 1.27 1.55** 1.22 −1.12 1.09 PSMB5 proteasome unit, beta type, 5 19173 1.34 1.74 1.04 1.24** 1.02 −1.15 1.03 PSMB6 proteasome unit, beta type, 6 19175 1.54 1.83 1.08 1.24* 1.19 −1.23 −1.09 PSMB7 proteasome unit, beta type, 7 19177 1.46 1.33 1.07 1.15** 1.13 −1.17 −1.09 PSMB8 proteasome unit, beta type, 8 16913 −1.61 −2.00 −1.44 −1.51 −1.38 −1.23 −1.45** PSMB9 proteasome unit, beta type, 9 16912 1.24 −1.12 −1.31 −1.09 −1.10 −1.11 −1.30** PSMC1 proteasome 26S unit, ATPase, 1 19179 1.44 1.00 1.19 1.15* 1.11 −1.06 1.01 PSMC6 proteasome 26S unit, ATPase, 6 67089 1.18 1.21 1.09 −1.02 1.07 1.14 −1.16 PSMD1 proteasome 26S unit, non-ATPase, 1 70247 1.20 1.22 1.15 1.25** 1.09 1.03 1.15 PSMD11 proteasome 26S unit, non-ATPase, 11 69077 1.56 1.38 1.09 1.26* −1.17 1.16 1.32 PSMD12 proteasome 26S unit, non-ATPase, 12 66997 1.34 1.27 1.10 1.14 1.20 −1.03 1.04 PSMD13 proteasome 26S unit, non-ATPase, 13 23997 1.21 1.38 1.14 1.26* −1.03 −1.38 −1.42** PSMD14 proteasome 26S unit, non-ATPase, 14 59029 −1.39 −1.42 1.17 1.31* 1.31 1.01 1.17 PSMD2 proteasome 26S unit, non-ATPase, 2 21762 1.34 1.32 1.14 1.24* 1.10 1.09 1.30** PSMD3 proteasome 26S unit, non-ATPase, 3 22123 −1.35 −1.19 1.17 1.29* 1.08 1.04 1.22* PSMD4 proteasome 26S unit, non-ATPase, 4 19185 1.31 1.92 1.19 1.38** 1.03 −1.07 1.17* PSMD6 proteasome 26S unit, non-ATPase, 6 66413 1.17 1.33 1.10 1.14* 1.07 −1.06 1.04 PSMD7 proteasome 26S unit, non-ATPase, 7 17463 1.13 1.27 1.13 1.24* 1.02 −1.19 −1.22* PSMD8 proteasome 26S unit, non-ATPase, 8 57296 1.68 1.24 1.03 1.30** 1.16 −1.15 −1.00 PSME1 proteasome activator unit 1 19186 1.22 −1.00 −1.05 1.32** 1.27 −1.10 −1.09 VCP valosin−containing protein 269523 1.40 1.49 1.04 1.12 1.07 1.13 1.21**

1From Rosen et al. (2008), *Significantly different than control ($P\le .03$), **Significantly different than control ($P\le .0025$).