Table 5: Average fold change for genes related to peroxisome biogenesis in wild-type and PPARα-null male mice following a seven-day exposure to Wy-14,6431, PFOA1, or PFOS.

WTNull
SymbolGene nameEntrez no.Wy14,643 50 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kg

PECIperoxisome D3, D2-enoyl-
CoA isomerase
239861.733.151.611.87**1.961.421.57**
PEX1peroxisomal biogenesis
factor 1
713821.251.841.071.21**−1.021.101.14*
PEX11Aperoxisomal biogenesis
factor 11 alpha
186311.806.711.702.99**1.04−1.09−1.11
PEX12peroxisomal biogenesis
factor 12
1037371.071.361.111.17*1.091.171.30*
PEX13peroxisomal biogenesis
factor 13
721291.041.581.011.091.021.091.16*
PEX14peroxisomal biogenesis
factor 14
562731.061.241.031.25*1.031.051.13
PEX16peroxisomal biogenesis
factor 16
186331.511.441.131.33**−1.00−1.12−1.03
PEX19peroxisomal biogenesis
factor 19
192981.612.251.191.36**1.121.151.32**
PEX26peroxisomal biogenesis
factor 26
74043−1.32−1.861.011.261.011.291.10
PEX3peroxisomal biogenesis
factor 3
565351.501.771.131.37**−1.051.091.20*
PEX6peroxisomal biogenesis
factor 6
2248241.08−1.061.121.161.30−1.081.09
PXMP2peroxisomal membrane
protein 2
19301−1.22−1.29−1.08−1.20*−1.28−1.13−1.06
PXMP4peroxisomal membrane
protein 4
590381.622.091.611.62*1.99−1.031.01

1From Rosen et al. [1],
*Significantly different than control (P.03),
**Significantly different than control (P.0025).