Gene Expression Profiling in Wild-Type and PPAR𝛼-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR𝛼-Independent Effects

Table 5

Average fold change for genes related to peroxisome biogenesis in wild-type and PPAR$\alpha$-null male mice following a seven-day exposure to Wy-14,64$3^1$, PFOA¹, or PFOS.

					WT			Null
Symbol	Gene name	Entrez no.	Wy14,643 50 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg
PECI	peroxisome D3, D2-enoyl-; CoA isomerase	23986	1.73	3.15	1.61	1.87**	1.96	1.42	1.57**
PEX1	peroxisomal biogenesis; factor 1	71382	1.25	1.84	1.07	1.21**	−1.02	1.10	1.14*
PEX11A	peroxisomal biogenesis; factor 11 alpha	18631	1.80	6.71	1.70	2.99**	1.04	−1.09	−1.11
PEX12	peroxisomal biogenesis; factor 12	103737	1.07	1.36	1.11	1.17*	1.09	1.17	1.30*
PEX13	peroxisomal biogenesis; factor 13	72129	1.04	1.58	1.01	1.09	1.02	1.09	1.16*
PEX14	peroxisomal biogenesis; factor 14	56273	1.06	1.24	1.03	1.25*	1.03	1.05	1.13
PEX16	peroxisomal biogenesis; factor 16	18633	1.51	1.44	1.13	1.33**	−1.00	−1.12	−1.03
PEX19	peroxisomal biogenesis; factor 19	19298	1.61	2.25	1.19	1.36**	1.12	1.15	1.32**
PEX26	peroxisomal biogenesis; factor 26	74043	−1.32	−1.86	1.01	1.26	1.01	1.29	1.10
PEX3	peroxisomal biogenesis; factor 3	56535	1.50	1.77	1.13	1.37**	−1.05	1.09	1.20*
PEX6	peroxisomal biogenesis; factor 6	224824	1.08	−1.06	1.12	1.16	1.30	−1.08	1.09
PXMP2	peroxisomal membrane; protein 2	19301	−1.22	−1.29	−1.08	−1.20*	−1.28	−1.13	−1.06
PXMP4	peroxisomal membrane; protein 4	59038	1.62	2.09	1.61	1.62*	1.99	−1.03	1.01

¹From Rosen et al. [1],
*Significantly different than control ($P\le .03$),
**Significantly different than control ($P\le .0025$).