Gene Expression Profiling in Wild-Type and PPAR𝛼-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR𝛼-Independent Effects

Table 7

Average fold change for genes related to xenobiotic metabolism in wild-type and PPAR$\alpha$-null male mice following a seven-day exposure to Wy-14,64$3^1$, PFOA¹, or PFOS.

					WT			Null
Symbol	Gene name	Entrez no.	Wy14,643 50 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg
ADH1C	alcohol dehydrogenase 1C	11522	1.27	1.02	−1.00	1.02	−1.09	−1.02	−1.04
ADH5	alcohol dehydrogenase 5	11532	−1.18	1.10	1.09	−1.04	−1.02	1.11	1.14
ADH7	alcohol dehydrogenase 7	11529	−1.51	1.06	−1.01	−1.06	−1.71	−1.01	−1.01
ALDH1L1	aldehyde dehydrogenase 1L1	107747	−1.29	−1.85	−1.08	−1.18*	−1.41	1.76	1.68**
ALDH3B1	aldehyde dehydrogenase; 3B1	67689	1.12	1.04	−1.11	1.04	1.48	−1.03	−1.11
CES1	carboxylesterase 1	12623	1.43	2.29	1.61	2.62**	3.15	4.80	4.84**
CES2	carboxylesterase 2	234671	3.37	5.75	1.03	2.29	4.25	1.41	1.74*
CYP1A1	cytochrome; P450,1A1	13076	1.25	−1.93	−1.05	1.08	−1.02	1.34	1.49**
CYP1A2	cytochrome; P450,1A2	13077	−1.67	−1.24	−1.13	1.10	1.26	1.15	1.25*
CYP2A4	cytochrome; P450,2A4	13087	−4.26	1.33	1.08	2.01	5.82	1.28	1.57**
CYP2B10	cytochrome; P450,2B10	13088	1.31	4.39	3.50	5.92*	24.20	11.34	21.66**
CYP2C55	cytochrome; P450,2C55	72082	1.58	21.72	1.54	8.37*	110.35	10.57	25.18**
CYP2C37	cytochrome; P450,2C37	13096	−2.42	1.57	1.39	1.48	4.09	1.53	1.68
CYP2C38	cytochrome; P450, 2C38	13097	1.62	1.12	1.78	2.30**	−1.42	−1.26	1.03
CYP2C39	cytochrome; P450, 2C39	13098	2.45	1.51	1.65	1.51	−1.42	1.11	−1.01
CYP2C50	cytochrome; P450,2C50	107141	−2.63	1.31	1.11	1.19	1.71	1.34	1.26
CYP2C54	cytochrome; P450,2C54	404195	−2.98	1.44	1.16	1.14	1.87	1.29	1.35**
CYP2C70	cytochrome; P450,2C70	226105	−2.75	−4.22	−1.23	−1.68*	−1.05	−1.05	1.04
CYP2C65	cytochrome; P450,2C65	72303	1.44	1.63	−1.93	1.98	46.78	2.28	8.63**
CYP2D10	cytochrome; P450,2D10	13101	−1.47	−1.09	−1.02	−1.03	1.33	−1.00	1.02
CYP2D26	cytochrome; P450,2D26	76279	−1.17	−1.21	1.06	−1.01	−1.12	−1.03	−1.08
CYP3A11	cytochrome; P450,3A11	13112	−1.23	1.40	1.03	1.06	4.61	1.12	1.20
CYP3A41A	cytochrome; P450,3A41A	53973	−2.08	1.11	1.24	1.58*	2.01	1.39	1.25
CYP3A25	cytochrome; P450,3A25	56388	−1.94	−1.70	1.01	−1.01	1.04	1.13	1.12
CYP3A13	cytochrome; P450,3A13	13113	−1.54	1.19	1.22	1.38*	1.52	1.75	1.62**
EPHX1	epoxide hydrolase 1,; microsomal	13849	1.22	1.78	1.16	1.60*	1.82	1.33	1.59*
EPHX2	epoxide hydrolase 2,; cytoplasmic	13850	2.25	2.34	1.45	1.67**	1.04	1.05	1.07
GSTA3	glutathione; S-transferase A3	14859	1.08	−1.04	1.05	1.26	1.11	1.11	1.13
GSTA4	glutathione; S-transferase A4	14860	−2.01	−1.10	−1.02	1.52	1.37	−1.20	1.36
GSTA5	glutathione; S-transferase A5	14857	−1.12	1.44	1.19	2.76*	2.26	1.15	2.13
GSTK1	glutathione; S-transferase kappa 1	76263	1.85	1.43	1.02	−1.04	−1.30	−1.26	−1.27
GSTM1	glutathione; S-transferase M1	14863	−2.12	−1.56	−1.51	1.77	2.54	1.18	1.97
GSTM3	glutathione; S-transferase, mu 3	14864	−1.32	1.50	1.16	2.44*	1.83	1.57	2.59*
GSTM4	glutathione; S-transferase M4	14865	2.07	3.13	1.30	2.40*	2.48	1.40	2.63*
GSTP1	glutathione; S-transferase pi 1	14870	−2.79	4.14	−1.16	1.00	2.87	−1.06	−1.03
GSTT2	glutathione; S-transferase theta 2	14872	1.64	2.74	1.42	1.83**	1.13	1.16	1.43**
GSTT3	glutathione; S-transferase, theta 3	103140	2.10	1.13	1.41	1.61	1.77	1.30	1.85**
GSTZ1	glutathione; transferase zeta 1	14874	−1.36	−1.14	−1.03	−1.08	1.01	1.03	1.01
MGST1	microsomal; glutathione S-transferase 1	56615	1.28	1.24	−1.02	1.01	1.21	1.04	1.01
MGST3	microsomal; glutathione S-transferase 3	66447	1.73	1.60	1.24	1.80*	−1.54	−1.31	−1.06
POR	P450 (cytochrome); oxidoreductase	18984	−1.26	2.63	1.27	1.94	2.04	2.91	3.30**
UGT2B17	UDP glucuronosyltransferase; 2B17	71773	−3.90	−1.13	−1.03	1.02	1.24	1.03	−1.01
UGT2B4	UDP glucuronosyltransferase; 2B4	552899	−1.37	−1.93	−1.26	−1.23*	1.35	1.01	1.03
UGT2B7	UDP glucuronosyltransferase; 2B7	231396	−1.19	−1.20	−1.05	−1.05	1.16	1.04	−1.00

¹From Rosen et al. (2008),
*Significantly different than control ($P\le .03$),
**Significantly different than control ($P\le .0025$).