Table 7: Average fold change for genes related to xenobiotic metabolism in wild-type and PPARα-null male mice following a seven-day exposure to Wy-14,6431, PFOA1, or PFOS.

WTNull
SymbolGene nameEntrez no.Wy14,643 50 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kg

ADH1Calcohol dehydrogenase 1C115221.271.02−1.001.02−1.09−1.02−1.04
ADH5alcohol dehydrogenase 511532−1.181.101.09−1.04−1.021.111.14
ADH7alcohol dehydrogenase 711529−1.511.06−1.01−1.06−1.71−1.01−1.01
ALDH1L1aldehyde dehydrogenase 1L1107747−1.29−1.85−1.08−1.18*−1.411.761.68**
ALDH3B1aldehyde dehydrogenase
3B1
676891.121.04−1.111.041.48−1.03−1.11
CES1carboxylesterase 1126231.432.291.612.62**3.154.804.84**
CES2carboxylesterase 22346713.375.751.032.294.251.411.74*
CYP1A1cytochrome
P450,1A1
130761.25−1.93−1.051.08−1.021.341.49**
CYP1A2cytochrome
P450,1A2
13077−1.67−1.24−1.131.101.261.151.25*
CYP2A4cytochrome
P450,2A4
13087−4.261.331.082.015.821.281.57**
CYP2B10cytochrome
P450,2B10
130881.314.393.505.92*24.2011.3421.66**
CYP2C55cytochrome
P450,2C55
720821.5821.721.548.37*110.3510.5725.18**
CYP2C37cytochrome
P450,2C37
13096−2.421.571.391.484.091.531.68
CYP2C38cytochrome
P450, 2C38
130971.621.121.782.30**−1.42−1.261.03
CYP2C39cytochrome
P450, 2C39
130982.451.511.651.51−1.421.11−1.01
CYP2C50cytochrome
P450,2C50
107141−2.631.311.111.191.711.341.26
CYP2C54cytochrome
P450,2C54
404195−2.981.441.161.141.871.291.35**
CYP2C70cytochrome
P450,2C70
226105−2.75−4.22−1.23−1.68*−1.05−1.051.04
CYP2C65cytochrome
P450,2C65
723031.441.63−1.931.9846.782.288.63**
CYP2D10cytochrome
P450,2D10
13101−1.47−1.09−1.02−1.031.33−1.001.02
CYP2D26cytochrome
P450,2D26
76279−1.17−1.211.06−1.01−1.12−1.03−1.08
CYP3A11cytochrome
P450,3A11
13112−1.231.401.031.064.611.121.20
CYP3A41Acytochrome
P450,3A41A
53973−2.081.111.241.58*2.011.391.25
CYP3A25cytochrome
P450,3A25
56388−1.94−1.701.01−1.011.041.131.12
CYP3A13cytochrome
P450,3A13
13113−1.541.191.221.38*1.521.751.62**
EPHX1epoxide hydrolase 1,
microsomal
138491.221.781.161.60*1.821.331.59*
EPHX2epoxide hydrolase 2,
cytoplasmic
138502.252.341.451.67**1.041.051.07
GSTA3glutathione
S-transferase A3
148591.08−1.041.051.261.111.111.13
GSTA4glutathione
S-transferase A4
14860−2.01−1.10−1.021.521.37−1.201.36
GSTA5glutathione
S-transferase A5
14857−1.121.441.192.76*2.261.152.13
GSTK1glutathione
S-transferase kappa 1
762631.851.431.02−1.04−1.30−1.26−1.27
GSTM1glutathione
S-transferase M1
14863−2.12−1.56−1.511.772.541.181.97
GSTM3glutathione
S-transferase, mu 3
14864−1.321.501.162.44*1.831.572.59*
GSTM4glutathione
S-transferase M4
148652.073.131.302.40*2.481.402.63*
GSTP1glutathione
S-transferase pi 1
14870−2.794.14−1.161.002.87−1.06−1.03
GSTT2glutathione
S-transferase theta 2
148721.642.741.421.83**1.131.161.43**
GSTT3glutathione
S-transferase, theta 3
1031402.101.131.411.611.771.301.85**
GSTZ1glutathione
transferase zeta 1
14874−1.36−1.14−1.03−1.081.011.031.01
MGST1microsomal
glutathione S-transferase 1
566151.281.24−1.021.011.211.041.01
MGST3microsomal
glutathione S-transferase 3
664471.731.601.241.80*−1.54−1.31−1.06
PORP450 (cytochrome)
oxidoreductase
18984−1.262.631.271.942.042.913.30**
UGT2B17UDP glucuronosyltransferase
2B17
71773−3.90−1.13−1.031.021.241.03−1.01
UGT2B4UDP glucuronosyltransferase
2B4
552899−1.37−1.93−1.26−1.23*1.351.011.03
UGT2B7UDP glucuronosyltransferase
2B7
231396−1.19−1.20−1.05−1.051.161.04−1.00

1From Rosen et al. (2008),
*Significantly different than control (P.03),
**Significantly different than control (P.0025).