Table 8: Average fold change for genes related to cholesterol biosynthesis in wild-type and PPARα-null male mice following a seven-day exposure to Wy-14,6431, PFOA1, or PFOS.

WTNull
SymbolGene nameEntrez no.Wy14,643 50 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kg

CYP51cytochrome P450,
family 51
131212.851.371.272.10*1.372.991.93**
FDFT1farnesyl-diphosphate
farnesyltransferase 1
141372.301.281.291.73*1.092.001.92**
FDPSfarnesyl diphosphate
synthase
1101963.191.791.161.381.831.841.96**
HMGCR3-hydroxy-3-methylglutaryl
-CoA reductase
153571.79−1.081.191.97**1.201.851.80*
HMGCS13-hydroxy-3-methylglutaryl
-CoA synthase 1
2087156.671.791.151.61−1.063.111.86*
HMGCS23-hydroxy-3-methylglutaryl
-CoA synthase 2
153601.171.541.281.34*1.25−1.08−1.28*
IDI1isopentenyl-diphosphate
delta isomerase 1
3195543.141.611.351.621.401.961.57*
LSSlanosterol synthase169871.731.081.121.41−1.261.982.13**
MVKmevalonate kinase178551.45−1.241.121.22−1.021.571.52**
PMVKphosphomevalonate kinase686033.232.041.361.51*1.201.581.53**
SQLEsqualene epoxidase207753.101.051.171.461.262.251.98**

1From Rosen et al. (2008), *Significantly different than control (P.03),
**Significantly different than control (P.0025).