Gene Expression Profiling in Wild-Type and PPAR𝛼-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR𝛼-Independent Effects

Table 8

Average fold change for genes related to cholesterol biosynthesis in wild-type and PPAR$\alpha$-null male mice following a seven-day exposure to Wy-14,64$3^1$, PFOA¹, or PFOS.

					WT			Null
Symbol	Gene name	Entrez no.	Wy14,643 50 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg
CYP51	cytochrome P450,; family 51	13121	2.85	1.37	1.27	2.10*	1.37	2.99	1.93**
FDFT1	farnesyl-diphosphate; farnesyltransferase 1	14137	2.30	1.28	1.29	1.73*	1.09	2.00	1.92**
FDPS	farnesyl diphosphate; synthase	110196	3.19	1.79	1.16	1.38	1.83	1.84	1.96**
HMGCR	3-hydroxy-3-methylglutaryl; -CoA reductase	15357	1.79	−1.08	1.19	1.97**	1.20	1.85	1.80*
HMGCS1	3-hydroxy-3-methylglutaryl; -CoA synthase 1	208715	6.67	1.79	1.15	1.61	−1.06	3.11	1.86*
HMGCS2	3-hydroxy-3-methylglutaryl; -CoA synthase 2	15360	1.17	1.54	1.28	1.34*	1.25	−1.08	−1.28*
IDI1	isopentenyl-diphosphate; delta isomerase 1	319554	3.14	1.61	1.35	1.62	1.40	1.96	1.57*
LSS	lanosterol synthase	16987	1.73	1.08	1.12	1.41	−1.26	1.98	2.13**
MVK	mevalonate kinase	17855	1.45	−1.24	1.12	1.22	−1.02	1.57	1.52**
PMVK	phosphomevalonate kinase	68603	3.23	2.04	1.36	1.51*	1.20	1.58	1.53**
SQLE	squalene epoxidase	20775	3.10	1.05	1.17	1.46	1.26	2.25	1.98**

¹From Rosen et al. (2008), *Significantly different than control ($P\le .03$),
**Significantly different than control ($P\le .0025$).