Research Article
Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma
Table 2
Clinicopathologic parameters in relation to COX2 immunohistochemistry using TMA-2.
| Variable Categorization | Cytoplasmic COX2 immunoreactivity | Nuclear PPARG immunoreactivity | | analyzable | 0 () | 1+ () | 2+ () | 3+ () | | analyzable | 0 () | 1+ () | 2+ () | 3+ (n) |
| Primary malignant melanomas | | | | | | | | | | | | | Clark level | | | | | | | | | | | | | II | 4 | 3 | 1 | 0 | 0 | .004 | 2 | 2 | 0 | 0 | 0 | .793 | III | 14 | 3 | 6 | 3 | 2 | 12 | 11 | 1 | 0 | 0 | IV | 52 | 2 | 27 | 15 | 8 | 52 | 39 | 10 | 2 | 1 | V | 13 | 4 | 2 | 6 | 1 | 11 | 9 | 1 | 0 | 1 | Tumor thickness | | | | | | | | | | | | | 2.0 mm | 35 | 8 | 17 | 6 | 4 | .104 | 31 | 24 | 6 | 1 | 0 | .762 | 2.0 mm | 49 | 4 | 20 | 18 | 7 | 47 | 37 | 7 | 1 | 2 | Growth | | | | | | | | | | | | | SSM | 37 | 6 | 15 | 11 | 5 | .748 | 8 | 5 | 3 | 0 | 0 | .685 | LMM | 3 | 2 | 0 | 1 | 0 | 36 | 29 | 6 | 1 | 0 | NM | 29 | 2 | 14 | 9 | 4 | 5 | 4 | 1 | 0 | 0 | ALM | 6 | 1 | 3 | 1 | 1 | 27 | 21 | 3 | 1 | 2 | ONA | 9 | 1 | 5 | 2 | 1 | 2 | 2 | 0 | 0 | 0 | TP53 immunoreactivity | | | | | | | | | | | | | 5% | 67 | 11 | 28 | 20 | 8 | .308 | 63 | 49 | 10 | 2 | 2 | .883 | 5% | 15 | 0 | 8 | 4 | 3 | 15 | 12 | 3 | 0 | 0 | Ki-67 labeling index | | | | | | | | | | | | | 5% | 68 | 11 | 29 | 18 | 10 | .295 | 64 | 53 | 9 | 1 | 1 | .101 | 5% | 14 | 0 | 7 | 6 | 1 | 14 | 8 | 4 | 1 | 1 | Melanoma metastases | | | | | | | | | | | | | Lymph node | 42 | 3 | 9 | 4 | 26 | .013 | 42 | 32 | 6 | 2 | 2 | .136 | Skin | 56 | 6 | 27 | 6 | 17 | 53 | 32 | 18 | 1 | 2 | Benign nevi | | | | | | | | | | | | | Compound & junctional | 47 | 39 | 7 | 1 | 0 | .001 | 53 | 53 | 0 | 0 | 0 | — | Dermal | 21 | 15 | 6 | 0 | 0 | 45 | 45 | 0 | 0 | 0 | Congenital | 51 | 4 | 45 | 2 | 0 | 50 | 50 | 0 | 0 | 0 |
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, superfical spreading melanoma; LMM, lentigo maligna melanoma; NM, nodular melanoma; ALM, akro-lentiginous melanoma; NOS, not otherwise specified. ’s exact test (two-sided), bold face representing significant data.
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