Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma
Table 3
Univariate analysis of factors regarding tumor progression and death.
Variable Categorization
Tumor progression
Death
events
events
Age at diagnosis
60 years
48
25
0.7
48
7
0.6
60 years
40
18
40
7
Gender
female
39
15
0.06
39
5
0.4
male
49
28
49
9
Clark
II
5
0
0.4
5
0
0.3
III
15
8
15
2
IV
54
28
54
8
V
13
7
13
4
Tumor thickness
2.0 mm
38
14
0.03
38
4
0.2
2.0 mm
50
29
50
10
Ki67 labeling index
5%
33
17
0.7
33
7
0.9
5%
36
16
36
7
Cytoplasmic COX2 IHC
score 0
12
2
0.03
12
0
0.1
score 1+-3+
72
39
72
14
Nuclear PPARG IHC
score 0
61
28
0.2
61
11
0.6
score 1+-3+
17
10
17
2
initial and unifocal malignant melanomas were included; og rank test (two-sided), bold face representing significant data; to UICC: TNM Classification of Malignant Tumours. 6th edn (2002) Sobin LH, Wittekind CH (eds.) Wiley, New York.