PPAR-𝛼 Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice

Figure 2

Role of PPAR-$\alpha$ in the anti-inflammatory property of VB on clinical expression of DNBS-induced colitis and macroscopic damage score. Colon tissues from sham-treated mice (a), colon tissues from DNBS-treated PPAR-$\alpha$WT (b) or DNBS-treated PPAR-$\alpha$KO mice (c) from mice at 4 days post DNBS administration, and the colon tissues collected from DNBS-treated mice which have received VB treatment (d). The treatment of PPAR-$\alpha$WT with VB resulted in a significant decrease in the extent and severity of the macroscopic signs (d). The genetic absence of the PPAR-$\alpha$ receptor significantly reduced the effect of the VB treatment (e). The macroscopic damage score was made by two independent observers (f). Data are means $\pm$ SEM of 10 mice for each group. *$P<.01$ versus Sham; °$P<.05$ versus DNBS-WT group.

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