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PPAR Research
Volume 2010, Article ID 937123, 7 pages
Review Article

Regulation of PPAR Coactivator-1 Function and Expression in Muscle: Effect of Exercise

1School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3
2Muscle Health Research Centre, York University, Toronto, ON, Canada M3J 1P3
3Department of Biology, York University, Toronto, ON, Canada M3J 1P3

Received 7 May 2010; Accepted 1 July 2010

Academic Editor: Josep Bassaganya-Riera

Copyright © 2010 Giulia Uguccioni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


PPAR coactivator-1 (PGC-1 ) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscle via enhanced transcription of many nuclear genes encoding mitochondrial proteins. Stimuli such as exercise provoke the activation of signalling cascades that lead to the induction of PGC-1 . Posttranslational modifications also regulate the function of PGC-1 , with a multitude of upstream molecules targeting the protein to modify its activity and/or expression. Previous research has established a positive correlation between resistance to fatigue and skeletal muscle mitochondrial content. Recently, studies have begun to elucidate the specific role of PGC-1 in exercise-related skeletal muscle adaptations, with several studies identifying it as a dominant regulator of organelle synthesis. This paper will highlight the function, regulation, and expression of PGC-1 , as well as the role of the coactivator during exercise adaptations.