Consequences of PPAR_α Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids

Figure 1

Hepatic GCL activity in WT and PPARα-deficient (KO) mice fed diets containing either saturated FA (COCO diet) or ALA (LIN diet) for 8 weeks. Values are expressed as nmol/mg of protein/h for specific activity (a) and as mmol/liver/h for total activity (b). They are means ± standard errors for 7 mice per group, **KO group significantly different from WT group 𝑃<0.01. Columns sharing a same superscript letter, or without superscript letter, were not significantly different at 𝑃<0.05.

(a)

(b)