Consequences of PPAR_α Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids

Table 2

Markers of PPARα deficiency in WT and PPARα-null (KO) mice fed diets containing either saturated FA (COCO diet) or ALA (LIN diet) for 8 weeks.

	WT		KO		𝑃 values
	COCO	LIN	COCO	LIN	ANOVA	Genotype; (G)	Diet; (D)	Interaction G∗D
Body weight (g)	29.5 ± 0.5^b	29.6 ± 0.5^b	36.7 ± 1.0^a	32.7 ± 1.5^b	0.0001	0.0001	0.0379	0.0261
Liver weight (g)	1.07 ± 0.04^b	1.07 ± 0.06^b	1.55 ± 0.08^a	1.04 ± 0.04^b	<0.0001	0.0004	0.0001	0.0001
Liver weight (%)	3.88 ± 0.10^b	3.88 ± 0.25^b	4.50 ± 0.12^a	3.71 ± 0.12^b	0.0007	0.1403	0.0112	0.0123
EpAT weight (%)	2.31 ± 0.16^b	2.58 ± 0.19^ab	3.47 ± 0.28^a	2.91 ± 0.40^ab	0.0013	0.0038	0.5062	0.0720
IngAT weight (%)	1.46 ± 0.19^b	1.78 ± 0.12^ab	2.50 ± 0.23^a	1.79 ± 0.22^ab	0.0063	0.0090	0.3293	0.0102
Blood glucose (g/L)	1.94 ± 0.18^b	1.83 ± 0.21^b	1.48 ± 0.17^ab	1.17 ± 0.12^a	0.0001	0.0001	0.1892	0.4690
Plasma TG (mg/dL)	0.25 ± 0.02^a	0.30 ± 0.03^ab	0.39 ± 0.01^b	0.36 ± 0.05^ab	0.0231	0.0039	0.7881	0.3064
Plasma CT (mgd/L)	0.75 ± 0.02^b	0.62 ± 0.05^b	1.20 ± 0.07^a	0.84 ± 0.11^b	0.0001	0.0001	0.0015	0.0823

Values are means ± standard errors for 7 mice per group. Mean values within a row sharing a same superscript letter, or without superscript letter, were not significantly different at 𝑃<0.05.