Consequences of PPAR_α Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids

Table 6

Plasma hormones and cytokines concentrations in WT and PPARα-null (KO) mice fed diets containing either saturated FA (COCO diet) or ALA (LIN diet) for 8 weeks.

	WT		KO		𝑃 values
	COCO	LIN	COCO	LIN	ANOVA	Genotype; (G)	Diet; (D)	Interaction G∗D
Insulin (ng/mL)	1.68 ± 0.36	2.87 ± 0.54	2.66 ± 0.37	1.83 ± 0.77	0.2300	0.9510	0.7145	0.0531
Leptin (pg/mL)	222 ± 52.9	254 ± 71.54	179 ± 39.2	242 ± 57.9	0.7748	0.6541	0.4430	0.8041
Adiponectine (mg/mL)	8.11 ± 1.03^b	13.6 ± 1.37^a	6.95 ± 0.45^b	10.7 ± 0.81^ab	0.0005	0.0596	0.0002	0.3990
MCP 1 (pg/mL)	20.2 ± 4.55	18.3 ± 1.75	10.3 ± 1.89	13.8 ± 1.69	0.1040	0.0338	0.8119	0.4066
PAI 1 (ng/mL)	1.53 ± 0.19	1.65 ± 0.31	0.97 ± 0.21	1.65 ± 0.43	0.2241	0.3203	0.1616	0.3120

Values are means ± standard errors for 7 mice per group. Mean values within a row sharing a same superscript letter, or without superscript letter, were not significantly different at 𝑃<0.05.